AdipoUpX™ Human ARL6 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ARL6 MMLV Particle (Overexpression) is a high-titer, ready-to-use MMLV retroviral particle professionally engineered for the stable overexpression of the human ARL6 (BBS3) gene. This GTPase is essential for the recruitment of the BBSome to ciliary membranes. The MMLV vector integrates into the genome to provide long-lasting expression, making it a reliable tool for researching genetic obesity mechanisms. Every batch undergoes comprehensive quality control for titer, sterility, and mycoplasma, while supporting the flexible selection of fluorescent reporter genes.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: ARL6

Full Name: ARF like GTPase 6

Gene Symbol: BBS3; RP55

Gene ID: 84100

RefSeq ID-1: NP_001265222.1

RefSeq ID-2: NM_001278293.3

Summary: ARL6 (also known as BBS3) is a member of the ARF family of small GTP-binding proteins. It serves as a molecular switch that manages intracellular traffic, specifically directing proteins toward the primary cilium. This "ciliary trafficking" is essential for the proper transmission of metabolic signals. Mutations in ARL6 are associated with Bardet-Biedl syndrome, and a specific retinal transcript (BBS3L) is crucial for visual function, highlighting its multi-organ importance in human health.

AdipoUpX™ Human ARL6 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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