AdipoUpX™ Human EIF2S3 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human EIF2S3 MMLV Particle (Overexpression) is a high-titer, ready-to-use MMLV retroviral particle professionally engineered for the stable overexpression of the human EIF2S3 gene. This translation initiation factor is linked to MEHMO syndrome and metabolic dysfunction, making its stable expression vital for researching cellular stress responses. Stable genomic integration allows for the establishment of reliable, permanent cell lines for long-term study. Our platform supports the flexible selection of reporter genes and passes comprehensive quality control to ensure product efficacy.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: EIF2S3

Full Name: Eukaryotic translation initiation factor 2 subunit gamma

Gene Symbol: EIF2; EIF2G; MEHMO; eIF2gX; MRXSBRK; eIF-2gA; EIF2gamma

Gene ID: 1968

RefSeq ID-1: NP_001406.1

RefSeq ID-2: NM_001415.4

Summary: EIF2S3 provides the instructions for the largest subunit of the eIF2 complex, a GTP-binding protein essential for starting the process of protein synthesis. It specifically helps recruit the initiator tRNA to the ribosome. While fundamental to all cellular growth, mutations in this gene have been linked to specialized metabolic and developmental syndromes, including those involving glucose dysregulation and growth failure.

AdipoUpX™ Human EIF2S3 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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