AdipoUpX™ Human MC3R Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human MC3R Lentiviral Particle (Overexpression) is a powerful gene delivery tool specifically designed for the stable overexpression of the human MC3R gene. This system is a reliable asset for researching metabolic partitioning and the neuroendocrine control of feed efficiency. Genome integration enables the establishment of stable cell lines for long-term signaling studies. All particles undergo rigorous quality control screening, and our customizable platform allows clients to freely select key functional components to meet specific experimental needs.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: MC3R

Full Name: Melanocortin 3 receptor

Gene Symbol: MC3; OB20; OQTL; BMIQ9; MC3-R

Gene ID: 4159

RefSeq ID-1: NP_063941.3

RefSeq ID-2: NM_019888.3

Summary: MC3R encodes a G-protein-coupled receptor (GPCR) that recognizes both melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). While part of the melanocortin system, MC3R is expressed in tissues beyond the adrenal cortex and melanocytes, indicating a wider systemic role. Evidence from knockout models (increased fat mass despite reduced food intake) strongly suggests that MC3R is a significant regulator of energy homeostasis. Mutations in MC3R are consistently associated with increased susceptibility to obesity in humans.

AdipoUpX™ Human MC3R Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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