AdipoUpX™ Human ARL13B Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ARL13B Lentiviral Particle (Overexpression) is professionally engineered for the efficient and long-lasting overexpression of the human ARL13B gene. This small GTPase is a gold-standard marker for ciliary membranes and is critical for investigating the signaling pathways that regulate satiety and weight gain. Every batch is verified through comprehensive quality control screening (titer, sterility, and mycoplasma), ensuring that experimental results are safe and high-fidelity. Our vector system offers high flexibility for the selection of reporter genes for precise longitudinal validation.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: ARL13B

Full Name: ARF like GTPase 13B

Gene Symbol: JBTS8; ARL2L1

Gene ID: 200894

RefSeq ID-1: NP_001167621.1

RefSeq ID-2: NM_001174150.2

Summary: ARL13B is a small GTPase localized to the primary cilium, where it regulates ciliary formation and microtubule maintenance. As cilia are critical for sensing metabolic hormones like leptin, defects in ARL13B cause Joubert syndrome 8, a condition involving neurological deficits and potential metabolic sensing failures.

AdipoUpX™ Human ARL13B Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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