AdipoUpX™ Human ADRB3 MMLV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ADRB3 MMLV Particle (Overexpression) is a stable integration tool for the specific and efficient overexpression of the human ADRB3 gene. ADRB3 serves as a key receptor regulating lipolysis and thermogenesis in adipose tissue. This ready-to-use product allows systematic investigation into ADRB3-mediated catecholamine signaling and its role in energy expenditure in dividing host cells. It is an ideal tool for in vitro functional validation and pharmacological studies. Product quality is ensured by rigorous purification, titer validation, and comprehensive QC screening against contaminants.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Complete verification of the vector genome's integrity was achieved for every viral preparation using the PCR method.

Sterility Test: The final viral preparation was confirmed sterile after testing.

Mycoplasma Test: Mycoplasma contamination testing met all release specifications for all product lots.

Other QC: We also provide additional testing services tailored to specific project requirements. Additionally, we conduct customized assessments to analyze the expression levels and biological functions of genetically modified organisms.

Storage: The product must be immediately transferred to -80 °C storage upon its arrival.

Stability: For long-term storage, the product guarantees excellent stability for 6-12 months at -80°C. After thawing, refrigeration at 4°C allows use of the working solution for 2-3 weeks.

Shipping Condition: Our MMLV retroviral products are shipped using dry ice.

Handling Notes: Due to their high sensitivity to temperature fluctuations and damaging freeze-thaw cycles, viral particles should be aliquoted into low-protein-binding tubes immediately upon receipt to maintain titer and product integrity. This procedure must be conducted within a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: All products have undergone rigorous internal QC inspections as part of our company's commitment to product quality. However, due to the diversity and complexity of experimental conditions, users bear ultimate responsibility for product storage, handling, and compliance with all safety and biosafety protocols, and we offer no guarantee of product performance or experimental results in any specific application.

Target Profile

Gene Name: ADRB3

Full Name: Adrenoceptor beta 3

Gene Symbol: BETA3AR

Gene ID: 155

RefSeq ID: NM_000025.3, NP_000016.1

Summary: ADRB3 encodes the beta-3 adrenergic receptor, a G protein-coupled receptor found mainly on the surface of adipose cells. Activation of this receptor by catecholamines (such as norepinephrine) signals the cells to initiate lipolysis (fat breakdown) and thermogenesis (heat production) in brown and beige fat. ADRB3 is therefore a crucial pharmacological target for enhancing energy expenditure. Polymorphisms in the ADRB3 gene are frequently studied, as they are associated with individual differences in basal metabolic rate and susceptibility to obesity and type 2 diabetes.

AdipoUpX™ Human ADRB3 MMLV Particle (Overexpression)

Product Overview

Specification

Target Profile

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