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Protosappanin A
Cat. No.:
0225LY-0968
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Add to basket
Product Overview
Description:
Protosappanin A targets the CD14/TLR4 and JAK2-STAT3 pathways to provide anti-neuroinflammatory effects; it also acts as an immunosuppressant in heart transplants and demonstrates antimicrobial activity against MRSA as well as anti-HIV-1 properties.
Synonym:
PTA; 102036-28-2; Sappanol B; 3,10,11-trihydroxy-6H-dibenzo[b,d]oxocin-7(8H)-one; 5,14,15-trihydroxy-8-oxatricyclo[10.4.0.02,7]hexadeca-1(16),2(7),3,5,12,14-hexaen-10-one; 6H-Dibenz(b,d)oxocin-7(8H)-one, 3,10,11-trihydroxy-; 5,14,15-trihydroxy-8-oxatricyclo(10.4.0.02,7)hexadeca-1(16),2(7),3,5,12,14-hexaen-10-one; 3,10,11-trihydroxy-7,8-dihydro-6h-dibenz[b,d]oxocin-7-one
CAS No.:
102036-28-2
Compound CID:
128001
Formula:
C15H12O5
Formula Weight:
272.25
Specification
Targets&IC50:
HIV-1 (IN): 12.6 uM
Relative Density:
1.476 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Protosappanin A can be used in immunology research to study its immunosuppressive effects and potential in transplantation models.
Library Information
Target:
STAT; COX; TLR; JAK; NF-κB; NADPH-oxidase; IL receptor; NO synthase; IκB/IKK; TNF
Receptor:
IFN-γ; IKK; IL receptor; JAK; NADPH-oxidase; NF-κB; NO; STAT; TLR; TNF-α
Pathways:
Microbiology/Virology; Apoptosis; NF-κB; Immunology/Inflammation; JAK/STAT signaling; Stem cell regulation; Proteases/Proteasome; Neuronal signaling; Tyrosine kinase/adaptors
Plate Number:
AOCL-13
Plate Location:
d9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
225 mg/mL; 826.45 mM
