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MMV390048
Cat. No.:
0225LY-0669
Appearance:
Solid
Purity:
≥97%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
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Product Overview
Description:
MMV390048 is a novel antimalarial chemical that inhibits Plasmodium PI4K (Kdapp: 0.3 uM) by binding to its ATP site; it is highly specific, avoiding most human kinases to minimize safety risks.
Synonym:
1314883-11-8; 5-(4-(Methylsulfonyl)phenyl)-6'-(trifluoromethyl)-[3,3'-bipyridin]-2-amine; 5-(4-(Methylsulfonyl)phenyl)-6'-(trifluoromethyl)-3,3'-bipyridine-2-amine; (3,3'-Bipyridin)-2-amine, 5-(4-(methylsulfonyl)phenyl)-6'-(trifluoromethyl)-; 5-(4-methylsulfonylphenyl)-3-[6-(trifluoromethyl)pyridin-3-yl]pyridin-2-amine
CAS No.:
1314883-11-8
Compound CID:
53311393
Formula:
C18H14F3N3O2S
Formula Weight:
393.38
Specification
Targets&IC50:
PI4K (P. falciparum): (Kdapp) 0.3 μM
Relative Density:
1.385 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
MMV390048 can be used in parasitology research to study the inhibition of Plasmodium phosphatidylinositol 4-kinase.
Library Information
Target:
PI4K; Parasite protein
Receptor:
PI4K
Pathways:
Microbiology/Virology; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-9
Plate Location:
f6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
90 mg/mL; 228.79 mM
