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Vitamin B12 test kit

LipoKnoxa™ Human TFAM shRNA AAV Particle (Silencing)

Cat. No.: V0126XX320
Species: Human
Target Gene: TFAM
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human TFAM shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX320-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GGCGGAGTGGCAGGTATATAA CDS Inquiry
V0126XX320-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GTAAGTTCTTACCTTCGATTT CDS Inquiry
V0126XX320-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CGTCGCACAATAAAGAAACAA CDS Inquiry
V0126XX320-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GGCGGAGTGGCAGGTATATAA CDS Inquiry
V0126XX320-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GTAAGTTCTTACCTTCGATTT CDS Inquiry
V0126XX320-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CGTCGCACAATAAAGAAACAA CDS Inquiry
V0126XX320-7 AAV3 Lung; Liver; Smooth muscle GGCGGAGTGGCAGGTATATAA CDS Inquiry
V0126XX320-8 AAV3 Lung; Liver; Smooth muscle GTAAGTTCTTACCTTCGATTT CDS Inquiry
V0126XX320-9 AAV3 Lung; Liver; Smooth muscle CGTCGCACAATAAAGAAACAA CDS Inquiry
V0126XX320-10 AAV4 CNS; Retina; Heart; Lung; Kidney GGCGGAGTGGCAGGTATATAA CDS Inquiry
V0126XX320-11 AAV4 CNS; Retina; Heart; Lung; Kidney GTAAGTTCTTACCTTCGATTT CDS Inquiry
V0126XX320-12 AAV4 CNS; Retina; Heart; Lung; Kidney CGTCGCACAATAAAGAAACAA CDS Inquiry
V0126XX320-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GGCGGAGTGGCAGGTATATAA CDS Inquiry
V0126XX320-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GTAAGTTCTTACCTTCGATTT CDS Inquiry
V0126XX320-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CGTCGCACAATAAAGAAACAA CDS Inquiry
V0126XX320-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GGCGGAGTGGCAGGTATATAA CDS Inquiry
V0126XX320-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GTAAGTTCTTACCTTCGATTT CDS Inquiry
V0126XX320-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CGTCGCACAATAAAGAAACAA CDS Inquiry
V0126XX320-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GGCGGAGTGGCAGGTATATAA CDS Inquiry
V0126XX320-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GTAAGTTCTTACCTTCGATTT CDS Inquiry
V0126XX320-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CGTCGCACAATAAAGAAACAA CDS Inquiry
V0126XX320-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GGCGGAGTGGCAGGTATATAA CDS Inquiry
V0126XX320-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GTAAGTTCTTACCTTCGATTT CDS Inquiry
V0126XX320-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CGTCGCACAATAAAGAAACAA CDS Inquiry
V0126XX320-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GGCGGAGTGGCAGGTATATAA CDS Inquiry
V0126XX320-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GTAAGTTCTTACCTTCGATTT CDS Inquiry
V0126XX320-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CGTCGCACAATAAAGAAACAA CDS Inquiry
V0126XX320-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human TFAM shRNA AAV Particle (Silencing) targets TFAM, essential for the maintenance and transcription of mitochondrial DNA. Engineered with both high-potency U6 and physiologically refined miR30-based shRNA, this tool helps researchers study mitochondrial biogenesis in obesity. Multiple AAV serotypes are available to ensure precise delivery. Every batch undergoes comprehensive quality control, covering functional titer, sequence verification, and the total absence of pathogens.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: TFAM
Full Name: Transcription factor A, mitochondrial
Gene Symbol: TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; MTDPS15
Gene ID: 7019
RefSeq ID-1: NP_001257711.1
RefSeq ID-2: NM_001270782.2
Summary: TFAM encodes a mitochondrial transcription factor that contains two high-mobility group domains and is essential for mitochondrial DNA transcription, replication, and maintenance. By controlling mitochondrial biogenesis and function, TFAM plays a critical role in cellular energy production. Variations in TFAM expression or activity can influence mitochondrial efficiency and have been linked to metabolic phenotypes, including obesity and insulin resistance. Multiple transcript variants exist, and several pseudogenes are present in the human genome.

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