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Vitamin B12 test kit

LipoKnoxa™ Human ACACB shRNA AAV Particle (Silencing)

Cat. No.: V0126XX349
Species: Human
Target Gene: ACACB
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human ACACB shRNA AAV Particle (Silencing)
INQUIRY Datasheet MSDS
SPECIFIC INQUIRY
Fluorescent Reporters:
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX349-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ACCTCGTAGATGTGGAATTAA CDS Inquiry
V0126XX349-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCCGAGAACCTCAAGAAATTA CDS Inquiry
V0126XX349-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle TGTCCATCCGAGGCGACTTTA CDS Inquiry
V0126XX349-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ACCTCGTAGATGTGGAATTAA CDS Inquiry
V0126XX349-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCCGAGAACCTCAAGAAATTA CDS Inquiry
V0126XX349-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle TGTCCATCCGAGGCGACTTTA CDS Inquiry
V0126XX349-7 AAV3 Lung; Liver; Smooth muscle ACCTCGTAGATGTGGAATTAA CDS Inquiry
V0126XX349-8 AAV3 Lung; Liver; Smooth muscle CCCGAGAACCTCAAGAAATTA CDS Inquiry
V0126XX349-9 AAV3 Lung; Liver; Smooth muscle TGTCCATCCGAGGCGACTTTA CDS Inquiry
V0126XX349-10 AAV4 CNS; Retina; Heart; Lung; Kidney ACCTCGTAGATGTGGAATTAA CDS Inquiry
V0126XX349-11 AAV4 CNS; Retina; Heart; Lung; Kidney CCCGAGAACCTCAAGAAATTA CDS Inquiry
V0126XX349-12 AAV4 CNS; Retina; Heart; Lung; Kidney TGTCCATCCGAGGCGACTTTA CDS Inquiry
V0126XX349-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ACCTCGTAGATGTGGAATTAA CDS Inquiry
V0126XX349-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCCGAGAACCTCAAGAAATTA CDS Inquiry
V0126XX349-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle TGTCCATCCGAGGCGACTTTA CDS Inquiry
V0126XX349-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ACCTCGTAGATGTGGAATTAA CDS Inquiry
V0126XX349-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCCGAGAACCTCAAGAAATTA CDS Inquiry
V0126XX349-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle TGTCCATCCGAGGCGACTTTA CDS Inquiry
V0126XX349-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ACCTCGTAGATGTGGAATTAA CDS Inquiry
V0126XX349-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCCGAGAACCTCAAGAAATTA CDS Inquiry
V0126XX349-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle TGTCCATCCGAGGCGACTTTA CDS Inquiry
V0126XX349-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ACCTCGTAGATGTGGAATTAA CDS Inquiry
V0126XX349-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCCGAGAACCTCAAGAAATTA CDS Inquiry
V0126XX349-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle TGTCCATCCGAGGCGACTTTA CDS Inquiry
V0126XX349-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ACCTCGTAGATGTGGAATTAA CDS Inquiry
V0126XX349-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCCGAGAACCTCAAGAAATTA CDS Inquiry
V0126XX349-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle TGTCCATCCGAGGCGACTTTA CDS Inquiry
V0126XX349-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human ACACB shRNA AAV Particle (Silencing) targets ACACB, which regulates fatty acid oxidation in the mitochondria of muscle and heart. By utilizing high-potency U6-driven shRNA or physiologically optimized miR30 architectures, researchers can study strategies for enhancing fat burning. This product supports a wide range of AAV serotypes for diverse in vivo applications. Every batch is validated through stringent QC processes, including functional titering and sequence verification.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: ACACB
Full Name: Acetyl-CoA carboxylase beta
Gene Symbol: ACC2; ACCB; ACCbeta; HACC275; ACACbeta; ACC-beta
Gene ID: 32
RefSeq ID-1: NP_001084.3
RefSeq ID-2: NM_001093.4
Summary: ACACB encodes the β isoform of acetyl-CoA carboxylase, a key enzyme that regulates fatty acid oxidation through production of malonyl-CoA. By inhibiting mitochondrial fatty acid import, ACACB modulates lipid utilization rather than lipid synthesis, positioning it as an important regulator of energy balance and metabolic flexibility.

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