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AdipoUpX™ Human MC4R AAV Particle (Overexpression)
Cat. No.:
V1125XX13
Species:
Human
Target Gene:
MC4R
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1125XX13-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1125XX13-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1125XX13-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1125XX13-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1125XX13-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1125XX13-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1125XX13-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1125XX13-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1125XX13-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1125XX13-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human MC4R AAV Particle (Overexpression) has undergone comprehensive quality control and efficiently expresses the human MC4R gene, a key GPCR in the hypothalamic appetite regulation pathway. This makes them an ideal tool for studying downstream signaling mechanisms, α-MSH activation, and roles in energy balance. Additionally, our platform offers highly customizable services, allowing clients to freely select from multiple serotypes, cell-specific promoters, and fluorescent reporter genes for precise targeting and validation.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
MC4R
Full Name:
Melanocortin receptor 4
Gene Symbol:
BMIQ20
Gene ID:
4160
RefSeq ID:
NM_005912.3, NP_005903.2
Summary:
The MC4R gene encodes a membrane-bound receptor belonging to the melanocortin receptor family. It interacts with ligands such as adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH) via a G protein-coupled mechanism. MC4R is a key node in the central appetite regulation network, and its functional defects represent the most common genetic cause of autosomal dominant obesity in humans. Notably, this gene contains no introns.
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