Products
- Anti-Obesity Compound Library
- GPCR/G Protein-Targeted Compounds
- Immunology/Inflammation-Targeted Compounds
- JAK/STAT-Targeted Compounds
- MAPK-Targeted Compounds
- Membrane Transporter/Ion Channel-Targeted Compounds
- Metabolism-Targeted Compounds
- NF-κB-Targeted Compounds
- Microbiology/Virology-Targeted Compounds
- Neuronal Signaling-Targeted Compounds
- PI3K/Akt/mTOR-Targeted Compounds
- Oxidation-reduction-Targeted Compounds
- Proteases/Proteasome-Targeted Compounds
- Stem Cells/Wnt-Targeted Compounds
- Tyrosine Kinase/Adaptors-Targeted Compounds
- Ubiquitin-Targeted Compounds
Online Inquiry
AdipoUpX™ Human PHF21A AAV Particle (Overexpression)
Cat. No.:
V1225XX384
Species:
Human
Target Gene:
PHF21A
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
Add to basket
| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX384-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX384-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX384-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX384-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX384-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX384-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX384-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX384-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX384-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX384-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human PHF21A AAV Particle (Overexpression) is a ready-to-use viral particle product that achieves stable expression of the human PHF21A gene. It serves as an epigenetic regulator (BHC80) essential for investigating the programming of precursor cells into specialized metabolic tissues. To ensure experimental reliability, all products undergo rigorous quality control, including titer, sterility, and mycoplasma testing. Our customizable platform also supports the flexible inclusion of fluorescent reporter genes for longitudinal cell tracking.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
PHF21A
Full Name:
PHD finger protein 21A
Gene Symbol:
BHC80; NEDMS; BM-006; IDDBCS
Gene ID:
51317
RefSeq ID-1:
NP_001095272.1
RefSeq ID-2:
NM_001101802.3
Summary:
PHF21A encodes BHC80, a core component of the BRAF35/histone deacetylase (HDAC) repression complex known as BHC. This complex suppresses neuron-specific gene expression by binding to the repressor element-1 (RE1), also referred to as the neural restrictive silencer (NRS). Through epigenetic regulation of neuronal gene networks, PHF21A may indirectly influence hypothalamic pathways involved in appetite regulation, energy expenditure, and body weight control, processes that are central to the development of obesity.
Related Products
-
LipoKnoxa™ Human INPPL1 shRNA AAV Particle (Silencing)
-
LipoKnoxa™ Human FABP5 shRNA AAV Particle (Silencing)
-
LipoKnoxa™ Human BBS4 shRNA AAV Particle (Silencing)
-
LipoKnoxa™ Human SIRT1 shRNA AAV Particle (Silencing)
-
LipoKnoxa™ Human CCKAR shRNA AAV Particle (Silencing)
-
AdipoUpX™ Human IL10 AAV Particle (Overexpression)