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AdipoUpX™ Human IL10 AAV Particle (Overexpression)
Cat. No.:
V1225XX308
Species:
Human
Target Gene:
IL10
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX308-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX308-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX308-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX308-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX308-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX308-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX308-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX308-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX308-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX308-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human IL10 AAV Particle (Overexpression) is a ready-to-use, high-titer AAV product specifically designed for the stable overexpression of the human IL10 gene. It is a reliable tool for investigating anti-inflammatory responses and their ability to counteract obesity-induced insulin resistance. All viral products undergo rigorous internal quality control to ensure safety and efficacy. Our customizable platform also allows for the flexible selection of promoters and fluorescent labels for precise tracking.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
IL10
Full Name:
Interleukin 10
Gene Symbol:
CSIF; TGIF; GVHDS; IL-10; IL10A
Gene ID:
3586
RefSeq ID-1:
NP_000563.1
RefSeq ID-2:
NM_000572.3
Summary:
IL10 encodes an anti-inflammatory cytokine that plays a central role in immune regulation. By suppressing pro-inflammatory signaling pathways, IL-10 indirectly influences insulin sensitivity and metabolic homeostasis. Chronic inflammation is a recognized contributor to obesity, positioning IL10 as a modulator of obesity-associated inflammatory states.
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