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AdipoUpX™ Human UCP1 AAV Particle (Overexpression)
Cat. No.:
V1225XX212
Species:
Human
Target Gene:
UCP1
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX212-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX212-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX212-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX212-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX212-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX212-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX212-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX212-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX212-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX212-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human UCP1 AAV Particle (Overexpression) is a ready-to-use, high-titer AAV product that ensures efficient and stable expression of the human UCP1 gene. Specifically designed for validating the mechanisms of mitochondrial thermogenesis and "beigeing" of adipocytes, it serves as a reliable tool for accelerating anti-obesity research. Our customizable platform allows flexible selection of serotypes and fluorescent labels, with all batches passing comprehensive quality control screening.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
UCP1
Full Name:
Uncoupling protein 1
Gene Symbol:
UCP; SLC25A7
Gene ID:
7350
RefSeq ID-1:
NP_068605.1
RefSeq ID-2:
NM_021833.5
Summary:
UCP1 is a member of the mitochondrial uncoupling protein family within the larger mitochondrial anion carrier protein (MACP) family. It mediates the dissipation of the proton gradient across the inner mitochondrial membrane, uncoupling oxidative phosphorylation from ATP production and releasing energy as heat—a process also known as the mitochondrial proton leak. UCP1 is expressed exclusively in brown adipose tissue, a specialized thermogenic tissue, and contributes to adaptive heat generation. Its activity also reduces mitochondrial membrane potential, supporting energy expenditure in mammals.
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