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AdipoUpX™ Human ACOT11 AAV Particle (Overexpression)
Cat. No.:
V1225XX390
Species:
Human
Target Gene:
ACOT11
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX390-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX390-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX390-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX390-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX390-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX390-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX390-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX390-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX390-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX390-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human ACOT11 AAV Particle (Overexpression) is engineered for stable functional validation, achieving efficient expression of the human ACOT11 gene. This thioesterase is essential for investigating brown fat thermogenesis and activated fatty acid management. Clients can select from various AAV serotypes and cell-specific promoters for precise targeted delivery. Comprehensive quality control is also performed on all viral particle products to ensure experimental reproducibility and safety.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
ACOT11
Full Name:
Acyl-CoA thioesterase 11
Gene Symbol:
BFIT; THEA; THEM1; STARD14
Gene ID:
26027
RefSeq ID-1:
NP_056362.1
RefSeq ID-2:
NM_015547.4
Summary:
ACOT11 encodes an acyl-CoA thioesterase that converts activated fatty acyl-CoA molecules into free fatty acids and coenzyme A. In mouse models, expression of the ACOT11 homolog in brown adipose tissue is induced by cold exposure and suppressed by warmth, indicating a role in thermogenic regulation. Notably, higher expression levels have been observed in obesity-resistant mice compared with obesity-prone strains, suggesting that ACOT11 may protect against excessive fat accumulation. Multiple transcript variants arise from alternative splicing.
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