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AdipoUpX™ Human PRKACA AAV Particle (Overexpression)
Cat. No.:
V1225XX337
Species:
Human
Target Gene:
PRKACA
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX337-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX337-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX337-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX337-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX337-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX337-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX337-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX337-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX337-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX337-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human PRKACA AAV Particle (Overexpression) is a high-titer AAV product that ensures efficient and stable expression of the human PRKACA gene. Specifically designed for validating the role of PKA in hormone-induced lipolysis and thermogenic activation, it serves as a powerful tool for energy mobilization research. Our customizable platform allows flexible selection of serotypes and fluorescent labels, supported by rigorous internal quality control, including titer and purity validation.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
PRKACA
Full Name:
Protein kinase cAMP-activated catalytic subunit alpha
Gene Symbol:
CAFD1; PKACA; PPNAD4
Gene ID:
5566
RefSeq ID-1:
NP_001291278.1
RefSeq ID-2:
NM_001304349.1
Summary:
PRKACA encodes a catalytic subunit of protein kinase A (PKA), a central mediator of cAMP-dependent signaling. Upon cAMP binding, the PKA holoenzyme releases active catalytic subunits that phosphorylate numerous targets involved in metabolism, cell growth, and hormone signaling. Constitutive activation of PRKACA has been linked to adrenal hyperplasia and endocrine disorders. Multiple transcript variants and tissue-specific isoforms have been identified.
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