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Vitamin B12 test kit

LipoKnoxa™ Human PTPN1 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX304
Species: Human
Target Gene: PTPN1
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human PTPN1 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX304-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle TTTGACCATAGTCGGATTAAA CDS Inquiry
V0126XX304-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CTGTGATCGAAGGTGCCAAAT CDS Inquiry
V0126XX304-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GAAGCCCAAAGGAGTTACATT CDS Inquiry
V0126XX304-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle TTTGACCATAGTCGGATTAAA CDS Inquiry
V0126XX304-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CTGTGATCGAAGGTGCCAAAT CDS Inquiry
V0126XX304-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GAAGCCCAAAGGAGTTACATT CDS Inquiry
V0126XX304-7 AAV3 Lung; Liver; Smooth muscle TTTGACCATAGTCGGATTAAA CDS Inquiry
V0126XX304-8 AAV3 Lung; Liver; Smooth muscle CTGTGATCGAAGGTGCCAAAT CDS Inquiry
V0126XX304-9 AAV3 Lung; Liver; Smooth muscle GAAGCCCAAAGGAGTTACATT CDS Inquiry
V0126XX304-10 AAV4 CNS; Retina; Heart; Lung; Kidney TTTGACCATAGTCGGATTAAA CDS Inquiry
V0126XX304-11 AAV4 CNS; Retina; Heart; Lung; Kidney CTGTGATCGAAGGTGCCAAAT CDS Inquiry
V0126XX304-12 AAV4 CNS; Retina; Heart; Lung; Kidney GAAGCCCAAAGGAGTTACATT CDS Inquiry
V0126XX304-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle TTTGACCATAGTCGGATTAAA CDS Inquiry
V0126XX304-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CTGTGATCGAAGGTGCCAAAT CDS Inquiry
V0126XX304-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GAAGCCCAAAGGAGTTACATT CDS Inquiry
V0126XX304-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle TTTGACCATAGTCGGATTAAA CDS Inquiry
V0126XX304-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CTGTGATCGAAGGTGCCAAAT CDS Inquiry
V0126XX304-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GAAGCCCAAAGGAGTTACATT CDS Inquiry
V0126XX304-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle TTTGACCATAGTCGGATTAAA CDS Inquiry
V0126XX304-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CTGTGATCGAAGGTGCCAAAT CDS Inquiry
V0126XX304-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GAAGCCCAAAGGAGTTACATT CDS Inquiry
V0126XX304-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle TTTGACCATAGTCGGATTAAA CDS Inquiry
V0126XX304-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CTGTGATCGAAGGTGCCAAAT CDS Inquiry
V0126XX304-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GAAGCCCAAAGGAGTTACATT CDS Inquiry
V0126XX304-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle TTTGACCATAGTCGGATTAAA CDS Inquiry
V0126XX304-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CTGTGATCGAAGGTGCCAAAT CDS Inquiry
V0126XX304-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GAAGCCCAAAGGAGTTACATT CDS Inquiry
V0126XX304-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human PTPN1 shRNA AAV Particle (Silencing) focuses on the targeted inhibition of PTP1B, which dephosphorylates the insulin receptor. Silencing this gene using our U6 or miR30 systems provides a unique method to study enhanced insulin and leptin sensitivity. Our platform offers multiple AAV serotypes to ensure precise tissue targeting, with all batches validated for functional titer and microbial purity.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: PTPN1
Full Name: Protein tyrosine phosphatase non-receptor type 1
Gene Symbol: PTP1B
Gene ID: 5770
RefSeq ID-1: NP_001265547.1
RefSeq ID-2: NM_001278618.1
Summary: PTPN1 is the archetypal member of the protein tyrosine phosphatase family, responsible for removing phosphate groups from tyrosine residues. It acts as a major metabolic "off-switch" by dephosphorylating the insulin receptor and the leptin-related JAK2 kinase. High levels of PTP1B activity lead to both insulin and leptin resistance, which are core drivers of obesity. Consequently, inhibiting this enzyme is a major area of pharmaceutical research for treating metabolic syndrome.

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