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Vitamin B12 test kit

LipoKnoxa™ Human STEAP4 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX381
Species: Human
Target Gene: STEAP4
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human STEAP4 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX381-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GTGATTCCTATTCGATATTAT CDS Inquiry
V0126XX381-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GCAGGTGTTTGTGTGTGGAAA CDS Inquiry
V0126XX381-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCAAGCAAAGAGTGATGGATA CDS Inquiry
V0126XX381-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GTGATTCCTATTCGATATTAT CDS Inquiry
V0126XX381-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GCAGGTGTTTGTGTGTGGAAA CDS Inquiry
V0126XX381-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCAAGCAAAGAGTGATGGATA CDS Inquiry
V0126XX381-7 AAV3 Lung; Liver; Smooth muscle GTGATTCCTATTCGATATTAT CDS Inquiry
V0126XX381-8 AAV3 Lung; Liver; Smooth muscle GCAGGTGTTTGTGTGTGGAAA CDS Inquiry
V0126XX381-9 AAV3 Lung; Liver; Smooth muscle CCAAGCAAAGAGTGATGGATA CDS Inquiry
V0126XX381-10 AAV4 CNS; Retina; Heart; Lung; Kidney GTGATTCCTATTCGATATTAT CDS Inquiry
V0126XX381-11 AAV4 CNS; Retina; Heart; Lung; Kidney GCAGGTGTTTGTGTGTGGAAA CDS Inquiry
V0126XX381-12 AAV4 CNS; Retina; Heart; Lung; Kidney CCAAGCAAAGAGTGATGGATA CDS Inquiry
V0126XX381-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GTGATTCCTATTCGATATTAT CDS Inquiry
V0126XX381-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GCAGGTGTTTGTGTGTGGAAA CDS Inquiry
V0126XX381-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCAAGCAAAGAGTGATGGATA CDS Inquiry
V0126XX381-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GTGATTCCTATTCGATATTAT CDS Inquiry
V0126XX381-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GCAGGTGTTTGTGTGTGGAAA CDS Inquiry
V0126XX381-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCAAGCAAAGAGTGATGGATA CDS Inquiry
V0126XX381-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GTGATTCCTATTCGATATTAT CDS Inquiry
V0126XX381-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GCAGGTGTTTGTGTGTGGAAA CDS Inquiry
V0126XX381-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCAAGCAAAGAGTGATGGATA CDS Inquiry
V0126XX381-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GTGATTCCTATTCGATATTAT CDS Inquiry
V0126XX381-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GCAGGTGTTTGTGTGTGGAAA CDS Inquiry
V0126XX381-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCAAGCAAAGAGTGATGGATA CDS Inquiry
V0126XX381-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GTGATTCCTATTCGATATTAT CDS Inquiry
V0126XX381-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GCAGGTGTTTGTGTGTGGAAA CDS Inquiry
V0126XX381-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCAAGCAAAGAGTGATGGATA CDS Inquiry
V0126XX381-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human STEAP4 shRNA AAV Particle (Silencing) focuses on the inhibition of a key metalloreductase that modulates adipocyte inflammatory signaling and glucose metabolism. Engineered with both U6 and miR30-based shRNA frameworks, this tool allows for the exploration of insulin sensitivity in adipocytes and other cells. A diverse range of AAV serotypes is available for selection to achieve high-efficiency transduction. Each viral preparation is backed by comprehensive QC documentation, including sterility and functional titer verification.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: STEAP4
Full Name: STEAP4 metalloreductase
Gene Symbol: TIARP; STAMP2; SchLAH; TNFAIP9
Gene ID: 79689
RefSeq ID-1: NP_001192244.1
RefSeq ID-2: NM_001205315.2
Summary: STEAP4 encodes a Golgi-localized member of the STEAP family with metalloreductase activity, enabling the reduction of iron and copper ions in an NAD⁺-dependent manner. Functional studies in both human and animal models indicate that STEAP4 participates in adipocyte differentiation, lipid metabolism, and inflammatory regulation within adipose tissue, linking it to obesity-related metabolic processes. Multiple alternatively spliced isoforms have been identified.

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