LipoKnoxa™ Human MC2R shRNA Lentiviral Particle (Silencing)

Sub Cat. No.	TargetSeq	Region	Inquiry
V0126XX563-1	ATATGCTGGGCAGCCTATATA	CDS	Inquiry
V0126XX563-2	ACGTTGCCAAGTGCCAGAATA	3' UTR	Inquiry
V0126XX563-3	GTTCTATGTGAACAGTCTTAT	3' UTR	Inquiry
V0126XX563-4	Other		Inquiry

Product Overview

Description: LipoKnoxa™ Human MC2R shRNA Lentiviral Particle (Silencing) targets the ACTH receptor to study its role in cortisol production and fat metabolism. By offering both U6 and miR30-based shRNA systems, this tool helps researchers investigate hormonal obesity drivers. Each preparation is backed by exhaustive QC documentation, confirming functional titer and microbial purity.

Production Cell Line: HEK293T

Promoter: U6; CMV; EF1α; CAG; UBC

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Comprehensive sequencing and PCR analyses were performed to verify the accurate genomic sequence of all viral preparations.

Sterility Test: Confirmed sterile via rigorous microbial analysis; free of bacterial and fungal contamination.

Mycoplasma Test: Rigorous quality control testing has confirmed the absence of mycoplasma contamination in this viral preparation.

Other QC: Customized supplementary testing and in vitro/in vivo assessments are available to verify post-silencing gene expression and biological functionality, ensuring the viral preparations meet the specific potency requirements of your gene interference project.

Storage: Store at -80°C for long-term preservation. Immediate transfer upon delivery is required to prevent loss of viral activity.

Stability: Shelf life: 6–12 months at -80°C (extended stability up to 2 years). Post-thaw: Stable at 4°C for 2–3 weeks without significant degradation of functional titers.

Shipping Condition: Products are delivered on dry ice to maintain the cold chain. Upon arrival, please ensure the presence of dry ice and transfer the vials immediately to -80°C storage.

Handling Notes: Avoid repeated freeze-thaw cycles. Aliquot into low-protein-binding tubes immediately after receipt to maintain optimal activity. For safety and contamination control, all viral handling must be performed inside a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: We ensure product integrity through rigorous QC, but we do not guarantee results in specific research contexts. Proper storage, handling, and total compliance with biosafety laws and safety protocols remain the sole responsibility of the user.

Target Profile

Gene Name: MC2R

Full Name: Melanocortin 2 receptor

Gene Symbol: ACTHR

Gene ID: 4158

RefSeq ID-1: NP_000520.1

RefSeq ID-2: NM_000529.2

Summary: MC2R is a member of the melanocortin receptor family that is uniquely sensitive to adrenocorticotropic hormone (ACTH). It is expressed in the adrenal cortex, where it triggers the production of glucocorticoids. Mutations in this receptor lead to familial glucocorticoid deficiency, disrupting the hormonal axis that regulates stress and metabolic energy allocation.

LipoKnoxa™ Human MC2R shRNA Lentiviral Particle (Silencing)

Product Overview

Specification

Target Profile

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