IWR-1

Cat. No.: OB0225WX-1696

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: IWR-1 is a small molecule antagonist of the Wnt pathway that functions by increasing the stability of the axin-mediated destruction complex (EC50 = 0.2 μM).

Synonym: IWR-1-endo; Endo-IWR 1; 1127442-82-3; 4-[(3aR,4S,7R,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide; rel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide; IWR-1 endo; 4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide; IWR1-endo; MFCD18086875; IRW1; rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide; 4-[(1R,2S,6R,7S)-3,5-dioxo-4-azatricyclo[5.2.1.0{2,6}]dec-8-en-4-yl]-N-(quinolin-8-yl)benzamide; 4-[(1S,2R,6S,7R)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]-N-quinolin-8-ylbenzamide; Benzamide, 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-

CAS No.: 1127442-82-3

Compound CID: 44483163

Formula: C₂₅H₁₉N₃O₃

Formula Weight: 409.44

Specification

Targets&IC50: Wnt: 0.2 μM (EC50)

Relative Density: 1.425 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: IWR-1 is applied in developmental biology and regenerative medicine as a tankyrase inhibitor to investigate the biochemical stabilization of the beta-catenin destruction complex.