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IQ-1S free acid
Cat. No.:
0225LY-1051
Appearance:
Solid
Purity:
≥97%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
IQ-1S free acid functions as a specific and efficient c-Jun N-Terminal Kinase (JNK) inhibitor that effectively suppresses murine delayed-type hypersensitivity. It serves as a valuable small-molecule tool for studying JNK mechanisms in rheumatoid arthritis by mitigating inflammation and cartilage degradation; notably, its neutral form is the primary species at physiological pH.
Synonym:
IQ-1; IQ-1S; IQ-1S (free acid); 23146-22-7; IQ-1S; 11-nitroso-10H-indeno[1,2-b]quinoxaline; 11H-indeno[1,2-b]quinoxalin-11-one oxime; 11H-Indeno[1,2-b]quinoxalin-11-one, oxime; N-{11H-indeno[1,2-b]quinoxalin-11-ylidene}hydroxylamine; IQ-1Sfreeacid; Indeno[1,2-b]quinoxalin-6-one, oxime; 11h-indeno-[1,2-b]quinoxalin-11-one oxime
CAS No.:
23146-22-7
Compound CID:
619002
Formula:
C15H9N3
Formula Weight:
247.25
Specification
Targets&IC50:
NF-κB: 2.3±0.41 μM
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
IQ-1S free acid can be used in neurobiology to study the high-affinity inhibition of JNK isoforms in neuroprotective models.
Library Information
Target:
NF-κB; JNK
Receptor:
JNK1; JNK2; JNK3; NF-κB
Pathways:
NF-κB; MAPK
Plate Number:
AOCL-14
Plate Location:
e6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
18.33 mg/mL; 74.14 mM
