Givinostat (ITF2357)

Cat. No.: OB0225WX-2470

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Givinostat (ITF2357) is a potent pan-HDAC inhibitor with IC50 values of 10 nM, 7.5 nM, and 16 nM for maize HD2, HD1B, and HD1A, respectively.

Synonym: 732302-99-7; Givinostat hydrochloride monohydrate; Givinostat Hydrochloride Hydrate; Givinostat (ITF2357); ITF2357; ITF2357 (Givinostat); (6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate hydrochloride hydrate; [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate;hydrate;hydrochloride; ITF-2357 hydrochloride monohydrate; Givinostat (hydrochloride monohydrate); {6-[(diethylamino)methyl]naphthalen-2-yl}methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate hydrate hydrochloride; Givinostat hydrochloride (USAN); {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate hydrochloride hydrate; Carbamic acid, (4-((hydroxyamino)carbonyl)phenyl)-, (6-((diethylamino)methyl)-2-naphthalenyl)methyl ester, monohydrochloride, monohydrate

CAS No.: 732302-99-7

Compound CID: 9804991

Formula: C₂₄H₂₇N₃O₄·HCl·H₂O

Formula Weight: 475.97

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Givinostat (ITF2357) is applied in epigenetic and hematology research as a potent histone deacetylase (HDAC) inhibitor to study the modulation of pro-inflammatory cytokines and the regulation of hematopoietic cell proliferation.