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AZ31
Cat. No.:
OB0225WX-2350
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, CSFC, and LC-MS.
Size:
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Product Overview
Description:
AZ31 is a potent and selective ATM inhibitor featuring oral activity and IC50 values of <1.2 nM for the enzyme and 46 nM in intracellular environments.
Synonym:
AZ 31; AZ-31; 2088113-98-6; 4-((S)-1-(tetrahydro-2H-pyran-4-yl)ethylamino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide; 3-Quinolinecarboxamide, 6-(6-(methoxymethyl)-3-pyridinyl)-4-(((1S)-1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)-; 6-[6-(Methoxymethyl)pyridin-3-yl]-4-[[(1S)-1-(oxan-4-yl)ethyl]amino]quinoline-3-carboxamide; (S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide; 6-[6-(methoxymethyl)pyridin-3-yl]-4-{[(1S)-1-(oxan-4-yl)ethyl]amino}quinoline-3-carboxamide
CAS No.:
2088113-98-6
Compound CID:
134694318
Formula:
C24H28N4O3
Formula Weight:
420.5
Specification
Targets&IC50:
ATM: 46 nM; ATM (oral): 1.2 nM
Relative Density:
1.234 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
AZ31 is utilized in medicinal chemistry and oncology research as a potent ATR inhibitor to study the structural requirements for kinase binding and the modulation of the DNA damage response pathway.
Library Information
Target:
ATM/ATR
Receptor:
ATM; ATR
Pathways:
DNA damage/DNA repair; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-31
Plate Location:
b2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
25 mg/mL; 59.45 mM
