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AdipoUpX™ Human XBP1 AAV Particle (Overexpression)
Cat. No.:
V1225XX328
Species:
Human
Target Gene:
XBP1
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX328-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX328-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX328-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX328-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX328-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX328-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX328-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX328-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX328-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX328-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human XBP1 AAV Particle (Overexpression) has undergone comprehensive quality control and efficiently expresses the human XBP1 gene. As a key transcription factor in the endoplasmic reticulum (ER) stress response, it is an ideal tool for studying the unfolded protein response (UPR) and its role in metabolic dysfunction. Our platform offers highly customizable services, and safety is ensured by full QC screening (titer, sterility, and mycoplasma detection) for all viral products.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
XBP1
Full Name:
X-box binding protein 1
Gene Symbol:
XBP2; TREB5; XBP-1; TREB-5
Gene ID:
7494
RefSeq ID-1:
NP_001073007.1
RefSeq ID-2:
NM_001079539.2
Summary:
XBP1 encodes a basic leucine zipper (bZIP) transcription factor involved in the unfolded protein response. Under endoplasmic reticulum stress, XBP1 mRNA undergoes unconventional splicing mediated by IRE1, producing an active transcription factor that regulates genes controlling protein folding, secretion, and metabolic adaptation. The unspliced isoform functions as a negative regulator, enabling tight control of ER stress responses relevant to metabolic tissues.
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