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Vitamin B12 test kit

LipoKnoxa™ Human MC2R shRNA AAV Particle (Silencing)

Cat. No.: V0126XX353
Species: Human
Target Gene: MC2R
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human MC2R shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX353-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ATATGCTGGGCAGCCTATATA CDS Inquiry
V0126XX353-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ACGTTGCCAAGTGCCAGAATA 3' UTR Inquiry
V0126XX353-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GTTCTATGTGAACAGTCTTAT 3' UTR Inquiry
V0126XX353-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ATATGCTGGGCAGCCTATATA CDS Inquiry
V0126XX353-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ACGTTGCCAAGTGCCAGAATA 3' UTR Inquiry
V0126XX353-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GTTCTATGTGAACAGTCTTAT 3' UTR Inquiry
V0126XX353-7 AAV3 Lung; Liver; Smooth muscle ATATGCTGGGCAGCCTATATA CDS Inquiry
V0126XX353-8 AAV3 Lung; Liver; Smooth muscle ACGTTGCCAAGTGCCAGAATA 3' UTR Inquiry
V0126XX353-9 AAV3 Lung; Liver; Smooth muscle GTTCTATGTGAACAGTCTTAT 3' UTR Inquiry
V0126XX353-10 AAV4 CNS; Retina; Heart; Lung; Kidney ATATGCTGGGCAGCCTATATA CDS Inquiry
V0126XX353-11 AAV4 CNS; Retina; Heart; Lung; Kidney ACGTTGCCAAGTGCCAGAATA 3' UTR Inquiry
V0126XX353-12 AAV4 CNS; Retina; Heart; Lung; Kidney GTTCTATGTGAACAGTCTTAT 3' UTR Inquiry
V0126XX353-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ATATGCTGGGCAGCCTATATA CDS Inquiry
V0126XX353-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ACGTTGCCAAGTGCCAGAATA 3' UTR Inquiry
V0126XX353-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GTTCTATGTGAACAGTCTTAT 3' UTR Inquiry
V0126XX353-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ATATGCTGGGCAGCCTATATA CDS Inquiry
V0126XX353-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ACGTTGCCAAGTGCCAGAATA 3' UTR Inquiry
V0126XX353-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GTTCTATGTGAACAGTCTTAT 3' UTR Inquiry
V0126XX353-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ATATGCTGGGCAGCCTATATA CDS Inquiry
V0126XX353-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ACGTTGCCAAGTGCCAGAATA 3' UTR Inquiry
V0126XX353-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GTTCTATGTGAACAGTCTTAT 3' UTR Inquiry
V0126XX353-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ATATGCTGGGCAGCCTATATA CDS Inquiry
V0126XX353-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ACGTTGCCAAGTGCCAGAATA 3' UTR Inquiry
V0126XX353-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GTTCTATGTGAACAGTCTTAT 3' UTR Inquiry
V0126XX353-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ATATGCTGGGCAGCCTATATA CDS Inquiry
V0126XX353-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ACGTTGCCAAGTGCCAGAATA 3' UTR Inquiry
V0126XX353-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GTTCTATGTGAACAGTCTTAT 3' UTR Inquiry
V0126XX353-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human MC2R shRNA AAV Particle (Silencing) targets the ACTH receptor, involved in cortisol production and adipose tissue metabolism. By utilizing high-potency U6-driven shRNA or physiologically optimized miR30 architectures, researchers can study the hormonal drivers of visceral obesity. This product supports a wide range of AAV serotypes for diverse in vivo applications. Every batch is validated through stringent QC processes, including functional titering, sequence integrity, and sterility testing.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: MC2R
Full Name: Melanocortin 2 receptor
Gene Symbol: ACTHR
Gene ID: 4158
RefSeq ID-1: NP_000520.1
RefSeq ID-2: NM_000529.2
Summary: MC2R encodes the adrenocorticotropic hormone (ACTH) receptor, a member of the melanocortin receptor family. Unlike other melanocortin receptors, MC2R is selectively activated by ACTH and plays a central role in adrenal glucocorticoid production. Genetic defects in MC2R lead to familial glucocorticoid deficiency, with potential downstream effects on energy balance and metabolism.

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