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Vitamin B12 test kit

LipoKnoxa™ Human XBP1 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX348
Species: Human
Target Gene: XBP1
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human XBP1 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX348-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GAACAGCAAGTGGTAGATTTA CDS Inquiry
V0126XX348-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GACCCAGTCATGTTCTTCAAA CDS Inquiry
V0126XX348-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GCCTGTCTGTACTTCATTCAA 3' UTR Inquiry
V0126XX348-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GAACAGCAAGTGGTAGATTTA CDS Inquiry
V0126XX348-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GACCCAGTCATGTTCTTCAAA CDS Inquiry
V0126XX348-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GCCTGTCTGTACTTCATTCAA 3' UTR Inquiry
V0126XX348-7 AAV3 Lung; Liver; Smooth muscle GAACAGCAAGTGGTAGATTTA CDS Inquiry
V0126XX348-8 AAV3 Lung; Liver; Smooth muscle GACCCAGTCATGTTCTTCAAA CDS Inquiry
V0126XX348-9 AAV3 Lung; Liver; Smooth muscle GCCTGTCTGTACTTCATTCAA 3' UTR Inquiry
V0126XX348-10 AAV4 CNS; Retina; Heart; Lung; Kidney GAACAGCAAGTGGTAGATTTA CDS Inquiry
V0126XX348-11 AAV4 CNS; Retina; Heart; Lung; Kidney GACCCAGTCATGTTCTTCAAA CDS Inquiry
V0126XX348-12 AAV4 CNS; Retina; Heart; Lung; Kidney GCCTGTCTGTACTTCATTCAA 3' UTR Inquiry
V0126XX348-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GAACAGCAAGTGGTAGATTTA CDS Inquiry
V0126XX348-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GACCCAGTCATGTTCTTCAAA CDS Inquiry
V0126XX348-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GCCTGTCTGTACTTCATTCAA 3' UTR Inquiry
V0126XX348-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GAACAGCAAGTGGTAGATTTA CDS Inquiry
V0126XX348-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GACCCAGTCATGTTCTTCAAA CDS Inquiry
V0126XX348-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GCCTGTCTGTACTTCATTCAA 3' UTR Inquiry
V0126XX348-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GAACAGCAAGTGGTAGATTTA CDS Inquiry
V0126XX348-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GACCCAGTCATGTTCTTCAAA CDS Inquiry
V0126XX348-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GCCTGTCTGTACTTCATTCAA 3' UTR Inquiry
V0126XX348-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GAACAGCAAGTGGTAGATTTA CDS Inquiry
V0126XX348-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GACCCAGTCATGTTCTTCAAA CDS Inquiry
V0126XX348-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GCCTGTCTGTACTTCATTCAA 3' UTR Inquiry
V0126XX348-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GAACAGCAAGTGGTAGATTTA CDS Inquiry
V0126XX348-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GACCCAGTCATGTTCTTCAAA CDS Inquiry
V0126XX348-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GCCTGTCTGTACTTCATTCAA 3' UTR Inquiry
V0126XX348-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human XBP1 shRNA AAV Particle (Silencing) targets a key transcription factor in the endoplasmic reticulum (ER) stress response, critical for hepatic lipogenesis and insulin signaling. Engineered with both high-potency U6 and physiologically refined miR30-based shRNA, this tool allows researchers to model the impact of chronic ER stress on metabolic health. Multiple AAV serotypes are provided to ensure optimal delivery. Every preparation undergoes total QC verification—covering sequence identity and microbial contaminants.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: XBP1
Full Name: X-box binding protein 1
Gene Symbol: XBP2; TREB5; XBP-1; TREB-5
Gene ID: 7494
RefSeq ID-1: NP_001073007.1
RefSeq ID-2: NM_001079539.2
Summary: XBP1 encodes a basic leucine zipper (bZIP) transcription factor involved in the unfolded protein response. Under endoplasmic reticulum stress, XBP1 mRNA undergoes unconventional splicing mediated by IRE1, producing an active transcription factor that regulates genes controlling protein folding, secretion, and metabolic adaptation. The unspliced isoform functions as a negative regulator, enabling tight control of ER stress responses relevant to metabolic tissues.

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