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Vitamin B12 test kit

LipoKnoxa™ Human LIPC shRNA AAV Particle (Silencing)

Cat. No.: V0126XX270
Species: Human
Target Gene: LIPC
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human LIPC shRNA AAV Particle (Silencing)
INQUIRY Datasheet MSDS
SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX270-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CGAAGCCATGTTCACCTAATT CDS Inquiry
V0126XX270-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GCATGAGATGAAGACCAGATT CDS Inquiry
V0126XX270-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCATGTCACTACTCGGAACAA CDS Inquiry
V0126XX270-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CGAAGCCATGTTCACCTAATT CDS Inquiry
V0126XX270-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GCATGAGATGAAGACCAGATT CDS Inquiry
V0126XX270-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCATGTCACTACTCGGAACAA CDS Inquiry
V0126XX270-7 AAV3 Lung; Liver; Smooth muscle CGAAGCCATGTTCACCTAATT CDS Inquiry
V0126XX270-8 AAV3 Lung; Liver; Smooth muscle GCATGAGATGAAGACCAGATT CDS Inquiry
V0126XX270-9 AAV3 Lung; Liver; Smooth muscle CCATGTCACTACTCGGAACAA CDS Inquiry
V0126XX270-10 AAV4 CNS; Retina; Heart; Lung; Kidney CGAAGCCATGTTCACCTAATT CDS Inquiry
V0126XX270-11 AAV4 CNS; Retina; Heart; Lung; Kidney GCATGAGATGAAGACCAGATT CDS Inquiry
V0126XX270-12 AAV4 CNS; Retina; Heart; Lung; Kidney CCATGTCACTACTCGGAACAA CDS Inquiry
V0126XX270-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CGAAGCCATGTTCACCTAATT CDS Inquiry
V0126XX270-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GCATGAGATGAAGACCAGATT CDS Inquiry
V0126XX270-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCATGTCACTACTCGGAACAA CDS Inquiry
V0126XX270-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CGAAGCCATGTTCACCTAATT CDS Inquiry
V0126XX270-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GCATGAGATGAAGACCAGATT CDS Inquiry
V0126XX270-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCATGTCACTACTCGGAACAA CDS Inquiry
V0126XX270-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CGAAGCCATGTTCACCTAATT CDS Inquiry
V0126XX270-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GCATGAGATGAAGACCAGATT CDS Inquiry
V0126XX270-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCATGTCACTACTCGGAACAA CDS Inquiry
V0126XX270-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CGAAGCCATGTTCACCTAATT CDS Inquiry
V0126XX270-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GCATGAGATGAAGACCAGATT CDS Inquiry
V0126XX270-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCATGTCACTACTCGGAACAA CDS Inquiry
V0126XX270-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CGAAGCCATGTTCACCTAATT CDS Inquiry
V0126XX270-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GCATGAGATGAAGACCAGATT CDS Inquiry
V0126XX270-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCATGTCACTACTCGGAACAA CDS Inquiry
V0126XX270-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human LIPC shRNA AAV Particle (Silencing) targets Hepatic Lipase, which plays a major role in the remodeling of HDL and LDL particles. Utilizing an advanced RNAi framework that includes both U6 and miR30-based systems, researchers can effectively study the role of LIPC in dyslipidemia. Our platform offers multiple AAV serotypes (AAV8, etc.) for high-efficiency hepatic transduction. Each preparation is verified via total QC validation—including functional titer and mycoplasma detection—to ensure safety and reproducibility.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: LIPC
Full Name: Lipase C, hepatic type
Gene Symbol: HL; HTGL; LIPH; HDLCQ12
Gene ID: 3990
RefSeq ID-1: NP_000227.2
RefSeq ID-2: NM_000236.3
Summary: LIPC encodes hepatic lipase, an extracellular enzyme with phospholipase A1 and triacylglycerol lipase activities. It plays a central role in triglyceride catabolism, cholesterol homeostasis, and plasma lipoprotein remodeling. Dysregulation of LIPC activity has been linked to metabolic disorders, including obesity, hyperinsulinemia, type 2 diabetes mellitus, and cardiovascular disease, and it is considered a biomarker for metabolic dysfunction.

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