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AdipoUpX™ Human ABCA1 AAV Particle (Overexpression)
Cat. No.:
V1225XX282
Species:
Human
Target Gene:
ABCA1
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX282-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX282-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX282-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX282-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX282-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX282-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX282-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX282-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX282-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX282-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human ABCA1 AAV Particle (Overexpression) is a ready-to-use, high-titer AAV product that undergoes rigorous QC and ensures efficient and stable expression of the human ABCA1 gene through an optimized strong promoter. Specifically designed for rapid validation of ABCA1's role in cellular cholesterol efflux and HDL biogenesis, it serves as a reliable tool for accelerating lipid metabolism research. Our customizable platform allows for flexible selection of serotypes and fluorescent labels for targeted delivery and multifunctional tracking validation.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
ABCA1
Full Name:
ATP binding cassette subfamily A member 1
Gene Symbol:
TGD; ABC1; CERP; ABC-1; HDLDT1; HPALP1; HDLCQTL13
Gene ID:
19
RefSeq ID-1:
NP_005493.2
RefSeq ID-2:
NM_005502.3
Summary:
ABCA1 is a specialized membrane transporter that serves as the "gatekeeper" for cholesterol efflux. It pumps cholesterol and phospholipids out of cells to facilitate the biogenesis of high-density lipoprotein (HDL) particles. Because this pathway is essential for preventing cellular lipid overload, defects in ABCA1 lead to Tangier disease and severe HDL deficiency. Its function is central to managing the lipid imbalances that occur during the progression of obesity and atherosclerosis.
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