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AdipoUpX™ Human STEAP4 AAV Particle (Overexpression)
Cat. No.:
V1225XX361
Species:
Human
Target Gene:
STEAP4
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX361-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX361-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX361-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX361-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX361-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX361-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX361-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX361-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX361-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX361-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human STEAP4 AAV Particle (Overexpression) is a ready-to-use gene delivery tool designed for the long-term stable overexpression of the human STEAP4 gene. As a metalloreductase that protects adipocytes from inflammation-induced insulin resistance, it is a crucial asset for researching cellular defense mechanisms in obesity. Every batch is verified through comprehensive QC, including titer, sterility, and mycoplasma testing, ensuring experimental reproducibility. Our platform also supports the flexible selection of AAV serotypes and promoters for precise tissue-specific delivery.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
STEAP4
Full Name:
STEAP4 metalloreductase
Gene Symbol:
TIARP; STAMP2; SchLAH; TNFAIP9
Gene ID:
79689
RefSeq ID-1:
NP_001192244.1
RefSeq ID-2:
NM_001205315.2
Summary:
STEAP4 encodes a Golgi-localized member of the STEAP family with metalloreductase activity, enabling the reduction of iron and copper ions in an NAD⁺-dependent manner. Functional studies in both human and animal models indicate that STEAP4 participates in adipocyte differentiation, lipid metabolism, and inflammatory regulation within adipose tissue, linking it to obesity-related metabolic processes. Multiple alternatively spliced isoforms have been identified.
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