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Vitamin B12 test kit

LipoKnoxa™ Human PRKACA shRNA AAV Particle (Silencing)

Cat. No.: V0126XX357
Species: Human
Target Gene: PRKACA
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human PRKACA shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX357-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CAACCTTCCTTTCGGAGTAAT 3' UTR Inquiry
V0126XX357-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CAAGGACAACTCAAACTTATA CDS Inquiry
V0126XX357-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCAGAGTTCCTTGCATCTAAT 3' UTR Inquiry
V0126XX357-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CAACCTTCCTTTCGGAGTAAT 3' UTR Inquiry
V0126XX357-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CAAGGACAACTCAAACTTATA CDS Inquiry
V0126XX357-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCAGAGTTCCTTGCATCTAAT 3' UTR Inquiry
V0126XX357-7 AAV3 Lung; Liver; Smooth muscle CAACCTTCCTTTCGGAGTAAT 3' UTR Inquiry
V0126XX357-8 AAV3 Lung; Liver; Smooth muscle CAAGGACAACTCAAACTTATA CDS Inquiry
V0126XX357-9 AAV3 Lung; Liver; Smooth muscle CCAGAGTTCCTTGCATCTAAT 3' UTR Inquiry
V0126XX357-10 AAV4 CNS; Retina; Heart; Lung; Kidney CAACCTTCCTTTCGGAGTAAT 3' UTR Inquiry
V0126XX357-11 AAV4 CNS; Retina; Heart; Lung; Kidney CAAGGACAACTCAAACTTATA CDS Inquiry
V0126XX357-12 AAV4 CNS; Retina; Heart; Lung; Kidney CCAGAGTTCCTTGCATCTAAT 3' UTR Inquiry
V0126XX357-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CAACCTTCCTTTCGGAGTAAT 3' UTR Inquiry
V0126XX357-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CAAGGACAACTCAAACTTATA CDS Inquiry
V0126XX357-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCAGAGTTCCTTGCATCTAAT 3' UTR Inquiry
V0126XX357-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CAACCTTCCTTTCGGAGTAAT 3' UTR Inquiry
V0126XX357-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CAAGGACAACTCAAACTTATA CDS Inquiry
V0126XX357-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCAGAGTTCCTTGCATCTAAT 3' UTR Inquiry
V0126XX357-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CAACCTTCCTTTCGGAGTAAT 3' UTR Inquiry
V0126XX357-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CAAGGACAACTCAAACTTATA CDS Inquiry
V0126XX357-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCAGAGTTCCTTGCATCTAAT 3' UTR Inquiry
V0126XX357-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CAACCTTCCTTTCGGAGTAAT 3' UTR Inquiry
V0126XX357-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CAAGGACAACTCAAACTTATA CDS Inquiry
V0126XX357-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCAGAGTTCCTTGCATCTAAT 3' UTR Inquiry
V0126XX357-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CAACCTTCCTTTCGGAGTAAT 3' UTR Inquiry
V0126XX357-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CAAGGACAACTCAAACTTATA CDS Inquiry
V0126XX357-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCAGAGTTCCTTGCATCTAAT 3' UTR Inquiry
V0126XX357-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human PRKACA shRNA AAV Particle (Silencing) targets the catalytic subunit alpha of protein kinase A, a central enzyme in the regulation of lipolysis and glycogen metabolism. Silencing this gene using our U6 or miR30 systems provides a unique method to study cAMP-dependent metabolic control. Multiple AAV serotypes are available to optimize delivery. To ensure experimental success, every batch undergoes total quality control screening for sequence accuracy, functional titer, and microbial purity.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: PRKACA
Full Name: Protein kinase cAMP-activated catalytic subunit alpha
Gene Symbol: CAFD1; PKACA; PPNAD4
Gene ID: 5566
RefSeq ID-1: NP_001291278.1
RefSeq ID-2: NM_001304349.1
Summary: PRKACA encodes a catalytic subunit of protein kinase A (PKA), a central mediator of cAMP-dependent signaling. Upon cAMP binding, the PKA holoenzyme releases active catalytic subunits that phosphorylate numerous targets involved in metabolism, cell growth, and hormone signaling. Constitutive activation of PRKACA has been linked to adrenal hyperplasia and endocrine disorders. Multiple transcript variants and tissue-specific isoforms have been identified.

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