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Vitamin B12 test kit

LipoKnoxa™ Human NFKB1 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX344
Species: Human
Target Gene: NFKB1
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human NFKB1 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX344-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CGAATGACAGAGGCGTGTATA CDS Inquiry
V0126XX344-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GCCTGAACAAATGTTTCATTT CDS Inquiry
V0126XX344-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CGCCTGAATCATTCTCGATTT 3' UTR Inquiry
V0126XX344-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CGAATGACAGAGGCGTGTATA CDS Inquiry
V0126XX344-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GCCTGAACAAATGTTTCATTT CDS Inquiry
V0126XX344-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CGCCTGAATCATTCTCGATTT 3' UTR Inquiry
V0126XX344-7 AAV3 Lung; Liver; Smooth muscle CGAATGACAGAGGCGTGTATA CDS Inquiry
V0126XX344-8 AAV3 Lung; Liver; Smooth muscle GCCTGAACAAATGTTTCATTT CDS Inquiry
V0126XX344-9 AAV3 Lung; Liver; Smooth muscle CGCCTGAATCATTCTCGATTT 3' UTR Inquiry
V0126XX344-10 AAV4 CNS; Retina; Heart; Lung; Kidney CGAATGACAGAGGCGTGTATA CDS Inquiry
V0126XX344-11 AAV4 CNS; Retina; Heart; Lung; Kidney GCCTGAACAAATGTTTCATTT CDS Inquiry
V0126XX344-12 AAV4 CNS; Retina; Heart; Lung; Kidney CGCCTGAATCATTCTCGATTT 3' UTR Inquiry
V0126XX344-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CGAATGACAGAGGCGTGTATA CDS Inquiry
V0126XX344-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GCCTGAACAAATGTTTCATTT CDS Inquiry
V0126XX344-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CGCCTGAATCATTCTCGATTT 3' UTR Inquiry
V0126XX344-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CGAATGACAGAGGCGTGTATA CDS Inquiry
V0126XX344-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GCCTGAACAAATGTTTCATTT CDS Inquiry
V0126XX344-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CGCCTGAATCATTCTCGATTT 3' UTR Inquiry
V0126XX344-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CGAATGACAGAGGCGTGTATA CDS Inquiry
V0126XX344-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GCCTGAACAAATGTTTCATTT CDS Inquiry
V0126XX344-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CGCCTGAATCATTCTCGATTT 3' UTR Inquiry
V0126XX344-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CGAATGACAGAGGCGTGTATA CDS Inquiry
V0126XX344-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GCCTGAACAAATGTTTCATTT CDS Inquiry
V0126XX344-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CGCCTGAATCATTCTCGATTT 3' UTR Inquiry
V0126XX344-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CGAATGACAGAGGCGTGTATA CDS Inquiry
V0126XX344-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GCCTGAACAAATGTTTCATTT CDS Inquiry
V0126XX344-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CGCCTGAATCATTCTCGATTT 3' UTR Inquiry
V0126XX344-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human NFKB1 shRNA AAV Particle (Silencing) focuses on the targeted inhibition of the NF-kappaB p50 subunit, a central mediator of inflammation-induced insulin resistance. Utilizing both high-potency U6 systems and physiologically refined miR30-based shRNA, this tool allows for the exploration of chronic inflammation in obesity. To facilitate precise tissue targeting, we offer a diverse selection of AAV serotypes. Every preparation undergoes total QC verification—including functional titer and sterility—ensuring results are scientifically robust.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: NFKB1
Full Name: Nuclear factor kappa B subunit 1
Gene Symbol: KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta
Gene ID: 4790
RefSeq ID-1: NP_001158884.1
RefSeq ID-2: NM_001165412.2
Summary: NFKB1 encodes a precursor protein that undergoes proteasomal processing to generate a mature transcription factor subunit of the NF-κB complex. While the full-length protein acts as a transcriptional inhibitor, the processed form functions as a DNA-binding regulator of genes involved in inflammation, immunity, cell survival, and stress responses. Aberrant NF-κB signaling has been associated with chronic inflammation and metabolic disorders. Alternative splicing produces multiple isoforms with distinct regulatory properties.

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