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Vitamin B12 test kit

LipoKnoxa™ Human AFF4 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX226
Species: Human
Target Gene: AFF4
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human AFF4 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX226-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GCACGACCGTGAGTCATATAA CDS Inquiry
V0126XX226-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CTCTCGGAAGAGGACTATTAG CDS Inquiry
V0126XX226-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GTAAGAATTGGTTCGTCTAAA 3' UTR Inquiry
V0126XX226-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GCACGACCGTGAGTCATATAA CDS Inquiry
V0126XX226-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CTCTCGGAAGAGGACTATTAG CDS Inquiry
V0126XX226-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GTAAGAATTGGTTCGTCTAAA 3' UTR Inquiry
V0126XX226-7 AAV3 Lung; Liver; Smooth muscle GCACGACCGTGAGTCATATAA CDS Inquiry
V0126XX226-8 AAV3 Lung; Liver; Smooth muscle CTCTCGGAAGAGGACTATTAG CDS Inquiry
V0126XX226-9 AAV3 Lung; Liver; Smooth muscle GTAAGAATTGGTTCGTCTAAA 3' UTR Inquiry
V0126XX226-10 AAV4 CNS; Retina; Heart; Lung; Kidney GCACGACCGTGAGTCATATAA CDS Inquiry
V0126XX226-11 AAV4 CNS; Retina; Heart; Lung; Kidney CTCTCGGAAGAGGACTATTAG CDS Inquiry
V0126XX226-12 AAV4 CNS; Retina; Heart; Lung; Kidney GTAAGAATTGGTTCGTCTAAA 3' UTR Inquiry
V0126XX226-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GCACGACCGTGAGTCATATAA CDS Inquiry
V0126XX226-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CTCTCGGAAGAGGACTATTAG CDS Inquiry
V0126XX226-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GTAAGAATTGGTTCGTCTAAA 3' UTR Inquiry
V0126XX226-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GCACGACCGTGAGTCATATAA CDS Inquiry
V0126XX226-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CTCTCGGAAGAGGACTATTAG CDS Inquiry
V0126XX226-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GTAAGAATTGGTTCGTCTAAA 3' UTR Inquiry
V0126XX226-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GCACGACCGTGAGTCATATAA CDS Inquiry
V0126XX226-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CTCTCGGAAGAGGACTATTAG CDS Inquiry
V0126XX226-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GTAAGAATTGGTTCGTCTAAA 3' UTR Inquiry
V0126XX226-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GCACGACCGTGAGTCATATAA CDS Inquiry
V0126XX226-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CTCTCGGAAGAGGACTATTAG CDS Inquiry
V0126XX226-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GTAAGAATTGGTTCGTCTAAA 3' UTR Inquiry
V0126XX226-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GCACGACCGTGAGTCATATAA CDS Inquiry
V0126XX226-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CTCTCGGAAGAGGACTATTAG CDS Inquiry
V0126XX226-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GTAAGAATTGGTTCGTCTAAA 3' UTR Inquiry
V0126XX226-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human AFF4 shRNA AAV Particle (Silencing) enables the targeted knockdown of the AFF4 scaffold protein to investigate its regulatory role in adipogenesis and inflammatory gene expression. Our RNAi platform develops these tools with both U6 and miR30 systems to provide either maximal or regulated knockdown. To ensure superior delivery, we offer multiple AAV serotypes for tissue-specific tropism. Every product is backed by comprehensive QC documentation, confirming sequence integrity, functional titer, and the total absence of pathogens for optimal experimental reliability.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: AFF4
Full Name: ALF transcription elongation factor 4
Gene Symbol: MCEF; CHOPS; AF5Q31
Gene ID: 27125
RefSeq ID-1: NP_055238.1
RefSeq ID-2: NM_014423.4
Summary: AFF4 encodes a transcriptional regulator belonging to the AF4 family and functions as a core component of the positive transcription elongation factor b (P-TEFb) complex. Through its role in transcriptional elongation, AFF4 influences gene expression programs critical for cell growth and differentiation. Chromosomal rearrangements involving AFF4 and the MLL gene have been identified in infant acute lymphoblastic leukemia, indicating its significance in transcriptional control and disease pathogenesis. Emerging evidence also supports broader roles for AFF4 in cellular regulation relevant to metabolic research.

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