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Vitamin B12 test kit

LipoKnoxa™ Human PHB1 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX408
Species: Human
Target Gene: PHB1
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human PHB1 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX408-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ATCACTTCAGATCTCTAATTA 3' UTR Inquiry
V0126XX408-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCCAGAAATCACTGTGAAATT 3' UTR Inquiry
V0126XX408-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CGTGGTGAACTCTGCCTTATA CDS Inquiry
V0126XX408-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ATCACTTCAGATCTCTAATTA 3' UTR Inquiry
V0126XX408-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCCAGAAATCACTGTGAAATT 3' UTR Inquiry
V0126XX408-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CGTGGTGAACTCTGCCTTATA CDS Inquiry
V0126XX408-7 AAV3 Lung; Liver; Smooth muscle ATCACTTCAGATCTCTAATTA 3' UTR Inquiry
V0126XX408-8 AAV3 Lung; Liver; Smooth muscle CCCAGAAATCACTGTGAAATT 3' UTR Inquiry
V0126XX408-9 AAV3 Lung; Liver; Smooth muscle CGTGGTGAACTCTGCCTTATA CDS Inquiry
V0126XX408-10 AAV4 CNS; Retina; Heart; Lung; Kidney ATCACTTCAGATCTCTAATTA 3' UTR Inquiry
V0126XX408-11 AAV4 CNS; Retina; Heart; Lung; Kidney CCCAGAAATCACTGTGAAATT 3' UTR Inquiry
V0126XX408-12 AAV4 CNS; Retina; Heart; Lung; Kidney CGTGGTGAACTCTGCCTTATA CDS Inquiry
V0126XX408-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ATCACTTCAGATCTCTAATTA 3' UTR Inquiry
V0126XX408-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCCAGAAATCACTGTGAAATT 3' UTR Inquiry
V0126XX408-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CGTGGTGAACTCTGCCTTATA CDS Inquiry
V0126XX408-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ATCACTTCAGATCTCTAATTA 3' UTR Inquiry
V0126XX408-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCCAGAAATCACTGTGAAATT 3' UTR Inquiry
V0126XX408-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CGTGGTGAACTCTGCCTTATA CDS Inquiry
V0126XX408-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ATCACTTCAGATCTCTAATTA 3' UTR Inquiry
V0126XX408-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCCAGAAATCACTGTGAAATT 3' UTR Inquiry
V0126XX408-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CGTGGTGAACTCTGCCTTATA CDS Inquiry
V0126XX408-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ATCACTTCAGATCTCTAATTA 3' UTR Inquiry
V0126XX408-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCCAGAAATCACTGTGAAATT 3' UTR Inquiry
V0126XX408-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CGTGGTGAACTCTGCCTTATA CDS Inquiry
V0126XX408-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ATCACTTCAGATCTCTAATTA 3' UTR Inquiry
V0126XX408-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCCAGAAATCACTGTGAAATT 3' UTR Inquiry
V0126XX408-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CGTGGTGAACTCTGCCTTATA CDS Inquiry
V0126XX408-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human PHB1 shRNA AAV Particle (Silencing) focuses on the inhibition of prohibitin 1, which regulates mitochondrial function and adipocyte signaling. Engineered with both U6 and miR30-based shRNA systems, this tool allows for the exploration of mitochondrial integrity in metabolic disease. Multiple AAV serotypes are provided to ensure optimal delivery. Every preparation is verified through thorough QC validation, including high-precision titer assays and sterility checks.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: PHB1
Full Name: Prohibitin 1
Gene Symbol: PHB; BAP32; HEL-215; HEL-S-54e
Gene ID: 5245
RefSeq ID-1: NP_001268425.1
RefSeq ID-2: NM_001281496.2
Summary: PHB1 is a highly conserved gene whose product has been implicated in cellular senescence, mitochondrial integrity, and tumor suppression. Antiproliferative effects have been attributed to regulatory elements within the 3′ untranslated region, which may act as a trans-acting RNA. Given its role in mitochondrial function and energy regulation, PHB1 has been linked to metabolic homeostasis and adipocyte biology, processes that are disrupted in obesity. Several pseudogenes and multiple splice variants have been reported.

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