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Vitamin B12 test kit

LipoKnoxa™ Human KSR2 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX284
Species: Human
Target Gene: KSR2
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human KSR2 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX284-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCAACCAGCAGAGGCAATAAT CDS Inquiry
V0126XX284-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CAGCCAGGGTGATGCGTTATT 3' UTR Inquiry
V0126XX284-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle TGTGCGAGACTGTGGAGAAAT CDS Inquiry
V0126XX284-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCAACCAGCAGAGGCAATAAT CDS Inquiry
V0126XX284-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CAGCCAGGGTGATGCGTTATT 3' UTR Inquiry
V0126XX284-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle TGTGCGAGACTGTGGAGAAAT CDS Inquiry
V0126XX284-7 AAV3 Lung; Liver; Smooth muscle CCAACCAGCAGAGGCAATAAT CDS Inquiry
V0126XX284-8 AAV3 Lung; Liver; Smooth muscle CAGCCAGGGTGATGCGTTATT 3' UTR Inquiry
V0126XX284-9 AAV3 Lung; Liver; Smooth muscle TGTGCGAGACTGTGGAGAAAT CDS Inquiry
V0126XX284-10 AAV4 CNS; Retina; Heart; Lung; Kidney CCAACCAGCAGAGGCAATAAT CDS Inquiry
V0126XX284-11 AAV4 CNS; Retina; Heart; Lung; Kidney CAGCCAGGGTGATGCGTTATT 3' UTR Inquiry
V0126XX284-12 AAV4 CNS; Retina; Heart; Lung; Kidney TGTGCGAGACTGTGGAGAAAT CDS Inquiry
V0126XX284-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCAACCAGCAGAGGCAATAAT CDS Inquiry
V0126XX284-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CAGCCAGGGTGATGCGTTATT 3' UTR Inquiry
V0126XX284-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle TGTGCGAGACTGTGGAGAAAT CDS Inquiry
V0126XX284-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCAACCAGCAGAGGCAATAAT CDS Inquiry
V0126XX284-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CAGCCAGGGTGATGCGTTATT 3' UTR Inquiry
V0126XX284-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle TGTGCGAGACTGTGGAGAAAT CDS Inquiry
V0126XX284-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCAACCAGCAGAGGCAATAAT CDS Inquiry
V0126XX284-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CAGCCAGGGTGATGCGTTATT 3' UTR Inquiry
V0126XX284-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle TGTGCGAGACTGTGGAGAAAT CDS Inquiry
V0126XX284-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCAACCAGCAGAGGCAATAAT CDS Inquiry
V0126XX284-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CAGCCAGGGTGATGCGTTATT 3' UTR Inquiry
V0126XX284-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle TGTGCGAGACTGTGGAGAAAT CDS Inquiry
V0126XX284-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCAACCAGCAGAGGCAATAAT CDS Inquiry
V0126XX284-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CAGCCAGGGTGATGCGTTATT 3' UTR Inquiry
V0126XX284-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle TGTGCGAGACTGTGGAGAAAT CDS Inquiry
V0126XX284-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human KSR2 shRNA AAV Particle (Silencing) targets the KSR2, a scaffold protein that modulates AMPK and ERK signaling to regulate energy balance. This AAV-mediated tool supports both U6 and miR30-based shRNA systems, allowing for the dissection of metabolic rate and appetite control pathways. A diverse spectrum of AAV serotypes is provided for in vivo studies. Each batch is verified via exhaustive quality control, covering sequence identity, functional potency, and the absence of mycoplasma.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: KSR2
Full Name: Kinase suppressor of ras 2
Gene ID: 283455
RefSeq ID-1: NP_775869.3
RefSeq ID-2: NM_173598.4
Summary: KSR2 is a scaffolding protein with serine/threonine kinase activity that is essential for energy homeostasis. It organizes the MAPK signaling cascade and is involved in calcium-mediated cellular signals. KSR2 is particularly important for thermogenesis (heat production) and the Ras protein signal transduction pathway. In humans, KSR2 deficiency is a known cause of severe obesity characterized by a low metabolic rate and increased appetite, emphasizing its role in systemic energy expenditure.

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