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Vitamin B12 test kit

LipoKnoxa™ Human MAGEL2 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX268
Species: Human
Target Gene: MAGEL2
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human MAGEL2 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX268-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CGCCTATATTATCATCAACAA CDS Inquiry
V0126XX268-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GCCCAATATGAATGCCTCAAA CDS Inquiry
V0126XX268-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CGAAGTGTTTGTCAGGCAGAA CDS Inquiry
V0126XX268-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CGCCTATATTATCATCAACAA CDS Inquiry
V0126XX268-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GCCCAATATGAATGCCTCAAA CDS Inquiry
V0126XX268-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CGAAGTGTTTGTCAGGCAGAA CDS Inquiry
V0126XX268-7 AAV3 Lung; Liver; Smooth muscle CGCCTATATTATCATCAACAA CDS Inquiry
V0126XX268-8 AAV3 Lung; Liver; Smooth muscle GCCCAATATGAATGCCTCAAA CDS Inquiry
V0126XX268-9 AAV3 Lung; Liver; Smooth muscle CGAAGTGTTTGTCAGGCAGAA CDS Inquiry
V0126XX268-10 AAV4 CNS; Retina; Heart; Lung; Kidney CGCCTATATTATCATCAACAA CDS Inquiry
V0126XX268-11 AAV4 CNS; Retina; Heart; Lung; Kidney GCCCAATATGAATGCCTCAAA CDS Inquiry
V0126XX268-12 AAV4 CNS; Retina; Heart; Lung; Kidney CGAAGTGTTTGTCAGGCAGAA CDS Inquiry
V0126XX268-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CGCCTATATTATCATCAACAA CDS Inquiry
V0126XX268-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GCCCAATATGAATGCCTCAAA CDS Inquiry
V0126XX268-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CGAAGTGTTTGTCAGGCAGAA CDS Inquiry
V0126XX268-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CGCCTATATTATCATCAACAA CDS Inquiry
V0126XX268-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GCCCAATATGAATGCCTCAAA CDS Inquiry
V0126XX268-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CGAAGTGTTTGTCAGGCAGAA CDS Inquiry
V0126XX268-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CGCCTATATTATCATCAACAA CDS Inquiry
V0126XX268-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GCCCAATATGAATGCCTCAAA CDS Inquiry
V0126XX268-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CGAAGTGTTTGTCAGGCAGAA CDS Inquiry
V0126XX268-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CGCCTATATTATCATCAACAA CDS Inquiry
V0126XX268-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GCCCAATATGAATGCCTCAAA CDS Inquiry
V0126XX268-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CGAAGTGTTTGTCAGGCAGAA CDS Inquiry
V0126XX268-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CGCCTATATTATCATCAACAA CDS Inquiry
V0126XX268-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GCCCAATATGAATGCCTCAAA CDS Inquiry
V0126XX268-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CGAAGTGTTTGTCAGGCAGAA CDS Inquiry
V0126XX268-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human MAGEL2 shRNA AAV Particle (Silencing) targets the gene linked to Prader-Willi and Schaaf-Yang syndromes, which involve severe hyperphagia and obesity. Silencing MAGEL2 via high-efficiency U6 or miR30 shRNA delivery allows for the exploration of hypothalamic protein recycling and satiety defects. Multiple AAV serotypes are provided for optimized delivery. Every batch is subjected to rigorous QC, including functional titer and mycoplasma testing, to guarantee experimental reproducibility.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: MAGEL2
Full Name: MAGE family member L2
Gene Symbol: PWLS; nM15; NDNL1; SHFYNG
Gene ID: 54551
RefSeq ID-1: NP_061939.3
RefSeq ID-2: NM_019066.5
Summary: MAGEL2 is a paternally expressed, imprinted gene located within the Prader–Willi syndrome (PWS) critical region on chromosome 15q11–q13. PWS is characterized by neonatal hypotonia, developmental delay, hyperphagia, and early-onset obesity. MAGEL2 shares structural similarity with necdin (NDN), a neuronal differentiation factor implicated in PWS pathogenesis, suggesting that MAGEL2 contributes to hypothalamic dysfunction underlying the obesity phenotype.

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