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AdipoUpX™ Human IL13 AAV Particle (Overexpression)
Cat. No.:
V1225XX385
Species:
Human
Target Gene:
IL13
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX385-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX385-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX385-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX385-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX385-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX385-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX385-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX385-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX385-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX385-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human IL13 AAV Particle (Overexpression) is engineered for in vivo and in vitro functional validation, ensuring the stable overexpression of the human IL13 gene. As an immunoregulatory cytokine that protects insulin sensitivity, it facilitates systematic investigation into immune-metabolic cross-talk. Clients can freely select from multiple AAV serotypes and cell-specific promoters to achieve precise targeted delivery. Comprehensive quality control is also performed on all viral products to ensure experimental reproducibility and safety.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
IL13
Full Name:
Interleukin 13
Gene Symbol:
P600; IL-13
Gene ID:
3596
RefSeq ID-1:
NP_002179.2
RefSeq ID-2:
NM_002188.2
Summary:
IL13 encodes a Th2-derived immunoregulatory cytokine that plays important roles in B-cell maturation and differentiation. It enhances CD23 and MHC class II expression and promotes immunoglobulin E (IgE) class switching in B cells. IL13 also suppresses macrophage activation, thereby reducing the production of pro-inflammatory cytokines and chemokines. While IL13 is a key mediator in allergen-induced asthma through IgE-independent mechanisms, it also contributes to immune regulation within adipose tissue. Altered IL13 signaling may influence obesity-associated inflammation and metabolic dysfunction. IL13 is located within a cytokine gene cluster on chromosome 5q, in close proximity to IL4.
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