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Vitamin B12 test kit

LipoKnoxa™ Human ARL6 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX276
Species: Human
Target Gene: ARL6
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human ARL6 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX276-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle TTTCAATTCAAGGAATCTATC 3' UTR Inquiry
V0126XX276-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CATTTGATTGTACGTAGAATG 3' UTR Inquiry
V0126XX276-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CGACGATCATTAACAAACTTA CDS Inquiry
V0126XX276-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle TTTCAATTCAAGGAATCTATC 3' UTR Inquiry
V0126XX276-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CATTTGATTGTACGTAGAATG 3' UTR Inquiry
V0126XX276-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CGACGATCATTAACAAACTTA CDS Inquiry
V0126XX276-7 AAV3 Lung; Liver; Smooth muscle TTTCAATTCAAGGAATCTATC 3' UTR Inquiry
V0126XX276-8 AAV3 Lung; Liver; Smooth muscle CATTTGATTGTACGTAGAATG 3' UTR Inquiry
V0126XX276-9 AAV3 Lung; Liver; Smooth muscle CGACGATCATTAACAAACTTA CDS Inquiry
V0126XX276-10 AAV4 CNS; Retina; Heart; Lung; Kidney TTTCAATTCAAGGAATCTATC 3' UTR Inquiry
V0126XX276-11 AAV4 CNS; Retina; Heart; Lung; Kidney CATTTGATTGTACGTAGAATG 3' UTR Inquiry
V0126XX276-12 AAV4 CNS; Retina; Heart; Lung; Kidney CGACGATCATTAACAAACTTA CDS Inquiry
V0126XX276-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle TTTCAATTCAAGGAATCTATC 3' UTR Inquiry
V0126XX276-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CATTTGATTGTACGTAGAATG 3' UTR Inquiry
V0126XX276-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CGACGATCATTAACAAACTTA CDS Inquiry
V0126XX276-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle TTTCAATTCAAGGAATCTATC 3' UTR Inquiry
V0126XX276-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CATTTGATTGTACGTAGAATG 3' UTR Inquiry
V0126XX276-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CGACGATCATTAACAAACTTA CDS Inquiry
V0126XX276-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle TTTCAATTCAAGGAATCTATC 3' UTR Inquiry
V0126XX276-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CATTTGATTGTACGTAGAATG 3' UTR Inquiry
V0126XX276-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CGACGATCATTAACAAACTTA CDS Inquiry
V0126XX276-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle TTTCAATTCAAGGAATCTATC 3' UTR Inquiry
V0126XX276-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CATTTGATTGTACGTAGAATG 3' UTR Inquiry
V0126XX276-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CGACGATCATTAACAAACTTA CDS Inquiry
V0126XX276-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle TTTCAATTCAAGGAATCTATC 3' UTR Inquiry
V0126XX276-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CATTTGATTGTACGTAGAATG 3' UTR Inquiry
V0126XX276-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CGACGATCATTAACAAACTTA CDS Inquiry
V0126XX276-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human ARL6 shRNA AAV Particle (Silencing) targets the small GTPase BBS3, which is required for the entry of the BBSome into the primary cilium. Engineered with both high-potency U6 and physiologically refined miR30-based shRNA, this tool allows researchers to model ciliary-dependent satiety signaling. Multiple AAV serotypes are provided to ensure optimal delivery. Every batch is validated through comprehensive quality control, including high-precision titering and mycoplasma testing.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: ARL6
Full Name: ARF like GTPase 6
Gene Symbol: BBS3; RP55
Gene ID: 84100
RefSeq ID-1: NP_001265222.1
RefSeq ID-2: NM_001278293.3
Summary: ARL6 (also known as BBS3) encodes a small GTP-binding protein belonging to the ARF-like family. It serves as a molecular switch that regulates the movement of cargo along the intracellular "highways" of the cell, specifically directed toward the primary cilium. Mutations in ARL6 disrupt this traffic, causing Bardet-Biedl syndrome. Because the primary cilium is the essential antenna for receptors that signal satiety, the trafficking defects caused by ARL6 mutations result in the inability of the brain to sense "fullness," leading to the characteristic obesity seen in BBS patients.

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