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AdipoUpX™ Human AFF4 AAV Particle (Overexpression)
Cat. No.:
V1225XX206
Species:
Human
Target Gene:
AFF4
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX206-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX206-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX206-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX206-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX206-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX206-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX206-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX206-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX206-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX206-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human AFF4 AAV Particle (Overexpression) is a high-titer AAV product that ensures efficient expression of the human AFF4 gene, a central component of the super elongation complex. It serves as a reliable tool for exploring the transcriptional regulation of genes involved in adipogenesis and systemic growth. The platform allows for flexible selection of serotypes for targeted delivery, and comprehensive quality control is performed to ensure the integrity and purity of the viral particles.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
AFF4
Full Name:
ALF transcription elongation factor 4
Gene Symbol:
MCEF; CHOPS; AF5Q31
Gene ID:
27125
RefSeq ID-1:
NP_055238.1
RefSeq ID-2:
NM_014423.4
Summary:
AFF4 encodes a transcriptional regulator belonging to the AF4 family and functions as a core component of the positive transcription elongation factor b (P-TEFb) complex. Through its role in transcriptional elongation, AFF4 influences gene expression programs critical for cell growth and differentiation. Chromosomal rearrangements involving AFF4 and the MLL gene have been identified in infant acute lymphoblastic leukemia, indicating its significance in transcriptional control and disease pathogenesis. Emerging evidence also supports broader roles for AFF4 in cellular regulation relevant to metabolic research.
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