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AdipoUpX™ Human FGF21 AAV Particle (Overexpression)
Cat. No.:
V1225XX298
Species:
Human
Target Gene:
FGF21
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX298-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX298-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX298-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX298-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX298-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX298-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX298-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX298-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX298-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX298-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human FGF21 AAV Particle (Overexpression) has undergone comprehensive quality control and efficiently expresses the human FGF21 gene. This metabolic hormone is a potent regulator of glucose uptake and energy expenditure, making it an ideal tool for studying thermogenesis and insulin sensitization. Our platform offers highly customizable services, allowing clients to select from various promoters and reporter genes for precise targeting, with safety guaranteed through comprehensive QC (titer, sterility, and mycoplasma).
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
FGF21
Full Name:
Fibroblast growth factor 21
Gene ID:
26291
RefSeq ID-1:
NP_061986.1
RefSeq ID-2:
NM_019113.4
Summary:
FGF21 encodes a secreted endocrine member of the fibroblast growth factor family that functions as a key regulator of metabolic homeostasis. The protein enhances glucose uptake in adipose tissue and modulates lipid and energy metabolism across multiple organs. FGF21 is widely recognized for its role in obesity, insulin sensitivity, and adaptive metabolic responses.
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