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AdipoUpX™ Human ITGAM AAV Particle (Overexpression)
Cat. No.:
V1225XX363
Species:
Human
Target Gene:
ITGAM
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX363-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX363-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX363-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX363-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX363-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX363-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX363-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX363-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX363-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX363-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human ITGAM AAV Particle (Overexpression) has undergone comprehensive quality control and efficiently expresses the human ITGAM (CD11b) gene, a key marker for macrophage infiltration in metabolic tissues. This makes it an ideal tool for studying the chronic low-grade inflammation associated with adipose tissue expansion. Safety and reliability are ensured by rigorous titer, sterility, and mycoplasma detection, while our platform offers highly customizable services for precise targeted delivery in immune-metabolic models.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
ITGAM
Full Name:
Integrin subunit alpha M
Gene Symbol:
CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
Gene ID:
3684
RefSeq ID-1:
NP_000623.2
RefSeq ID-2:
NM_000632.4
Summary:
ITGAM encodes the integrin αM subunit, which pairs with β2 integrin to form the leukocyte receptor Mac-1. This receptor mediates immune cell adhesion, migration, and phagocytosis. Through its role in immune cell recruitment and activation, ITGAM contributes to adipose tissue inflammation, a key pathological feature of obesity and metabolic dysfunction. Multiple transcript variants have been described.
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