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Vitamin B12 test kit

LipoKnoxa™ Human HMGCR shRNA AAV Particle (Silencing)

Cat. No.: V0126XX370
Species: Human
Target Gene: HMGCR
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human HMGCR shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX370-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ACCTACCTTACAGGGATTATA CDS Inquiry
V0126XX370-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ATCAACTTGTGTACTGATAAA 3' UTR Inquiry
V0126XX370-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GAGAATGTTATTGGATATATG CDS Inquiry
V0126XX370-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ACCTACCTTACAGGGATTATA CDS Inquiry
V0126XX370-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ATCAACTTGTGTACTGATAAA 3' UTR Inquiry
V0126XX370-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GAGAATGTTATTGGATATATG CDS Inquiry
V0126XX370-7 AAV3 Lung; Liver; Smooth muscle ACCTACCTTACAGGGATTATA CDS Inquiry
V0126XX370-8 AAV3 Lung; Liver; Smooth muscle ATCAACTTGTGTACTGATAAA 3' UTR Inquiry
V0126XX370-9 AAV3 Lung; Liver; Smooth muscle GAGAATGTTATTGGATATATG CDS Inquiry
V0126XX370-10 AAV4 CNS; Retina; Heart; Lung; Kidney ACCTACCTTACAGGGATTATA CDS Inquiry
V0126XX370-11 AAV4 CNS; Retina; Heart; Lung; Kidney ATCAACTTGTGTACTGATAAA 3' UTR Inquiry
V0126XX370-12 AAV4 CNS; Retina; Heart; Lung; Kidney GAGAATGTTATTGGATATATG CDS Inquiry
V0126XX370-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ACCTACCTTACAGGGATTATA CDS Inquiry
V0126XX370-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ATCAACTTGTGTACTGATAAA 3' UTR Inquiry
V0126XX370-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GAGAATGTTATTGGATATATG CDS Inquiry
V0126XX370-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ACCTACCTTACAGGGATTATA CDS Inquiry
V0126XX370-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ATCAACTTGTGTACTGATAAA 3' UTR Inquiry
V0126XX370-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GAGAATGTTATTGGATATATG CDS Inquiry
V0126XX370-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ACCTACCTTACAGGGATTATA CDS Inquiry
V0126XX370-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ATCAACTTGTGTACTGATAAA 3' UTR Inquiry
V0126XX370-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GAGAATGTTATTGGATATATG CDS Inquiry
V0126XX370-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ACCTACCTTACAGGGATTATA CDS Inquiry
V0126XX370-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ATCAACTTGTGTACTGATAAA 3' UTR Inquiry
V0126XX370-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GAGAATGTTATTGGATATATG CDS Inquiry
V0126XX370-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ACCTACCTTACAGGGATTATA CDS Inquiry
V0126XX370-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ATCAACTTGTGTACTGATAAA 3' UTR Inquiry
V0126XX370-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GAGAATGTTATTGGATATATG CDS Inquiry
V0126XX370-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human HMGCR shRNA AAV Particle (Silencing) targets the rate-limiting enzyme of the mevalonate pathway, HMG-CoA reductase. This silencing tool is built on an advanced RNAi platform supporting both U6 and miR30-based shRNA systems to study cholesterol metabolism. To facilitate precise delivery to the liver, multiple AAV serotypes are available. Each product is verified via thorough QC validation, including high-sensitivity titer assays and sterility checks, ensuring results are scientifically sound.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: HMGCR
Full Name: 3-Hydroxy-3-methylglutaryl-CoA reductase
Gene Symbol: MYPLG; LDLCQ3; LGMDR28
Gene ID: 3156
RefSeq ID-1: NP_000850.1
RefSeq ID-2: NM_000859.3
Summary: HMGCR is the rate-limiting enzyme in the cholesterol biosynthesis pathway. It is highly regulated by a negative feedback loop: when cholesterol levels are high, the enzyme is suppressed. This protein is the primary target of statin drugs; by inhibiting HMGCR, these medications lower plasma LDL cholesterol, making this gene a central focus in the study of atherosclerosis and lipid management.

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