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Vitamin B12 test kit

LipoKnoxa™ Human SREBF2 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX396
Species: Human
Target Gene: SREBF2
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human SREBF2 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX396-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GAAAGGCGGACAACCCATAAT CDS Inquiry
V0126XX396-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCTCCACCTCTCTCTCGATTT 3' UTR Inquiry
V0126XX396-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CCTTCAGTGCAACGGTCATTC CDS Inquiry
V0126XX396-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GAAAGGCGGACAACCCATAAT CDS Inquiry
V0126XX396-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCTCCACCTCTCTCTCGATTT 3' UTR Inquiry
V0126XX396-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CCTTCAGTGCAACGGTCATTC CDS Inquiry
V0126XX396-7 AAV3 Lung; Liver; Smooth muscle GAAAGGCGGACAACCCATAAT CDS Inquiry
V0126XX396-8 AAV3 Lung; Liver; Smooth muscle CCTCCACCTCTCTCTCGATTT 3' UTR Inquiry
V0126XX396-9 AAV3 Lung; Liver; Smooth muscle CCTTCAGTGCAACGGTCATTC CDS Inquiry
V0126XX396-10 AAV4 CNS; Retina; Heart; Lung; Kidney GAAAGGCGGACAACCCATAAT CDS Inquiry
V0126XX396-11 AAV4 CNS; Retina; Heart; Lung; Kidney CCTCCACCTCTCTCTCGATTT 3' UTR Inquiry
V0126XX396-12 AAV4 CNS; Retina; Heart; Lung; Kidney CCTTCAGTGCAACGGTCATTC CDS Inquiry
V0126XX396-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GAAAGGCGGACAACCCATAAT CDS Inquiry
V0126XX396-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCTCCACCTCTCTCTCGATTT 3' UTR Inquiry
V0126XX396-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CCTTCAGTGCAACGGTCATTC CDS Inquiry
V0126XX396-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GAAAGGCGGACAACCCATAAT CDS Inquiry
V0126XX396-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCTCCACCTCTCTCTCGATTT 3' UTR Inquiry
V0126XX396-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CCTTCAGTGCAACGGTCATTC CDS Inquiry
V0126XX396-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GAAAGGCGGACAACCCATAAT CDS Inquiry
V0126XX396-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCTCCACCTCTCTCTCGATTT 3' UTR Inquiry
V0126XX396-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CCTTCAGTGCAACGGTCATTC CDS Inquiry
V0126XX396-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GAAAGGCGGACAACCCATAAT CDS Inquiry
V0126XX396-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCTCCACCTCTCTCTCGATTT 3' UTR Inquiry
V0126XX396-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CCTTCAGTGCAACGGTCATTC CDS Inquiry
V0126XX396-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GAAAGGCGGACAACCCATAAT CDS Inquiry
V0126XX396-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCTCCACCTCTCTCTCGATTT 3' UTR Inquiry
V0126XX396-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CCTTCAGTGCAACGGTCATTC CDS Inquiry
V0126XX396-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human SREBF2 shRNA AAV Particle (Silencing) targets SREBP-2, the primary transcriptional activator for cholesterol biosynthesis. Engineered with both high-potency U6 and physiologically refined miR30-based shRNA, this tool helps researchers study cholesterol homeostasis in metabolic syndrome. Multiple AAV serotypes are provided to ensure optimal delivery. Every batch is verified through thorough QC validation, including sequence integrity and microbial safety testing.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: SREBF2
Full Name: Sterol regulatory element binding transcription factor 2
Gene Symbol: SREBP2; bHLHd2; SREBP-2
Gene ID: 6721
RefSeq ID-1: NP_004590.2
RefSeq ID-2: NM_004599.3
Summary: SREBF2 encodes a sterol-regulatory transcription factor that controls cholesterol biosynthesis and uptake. Through regulation of lipid metabolic genes, SREBF2 influences adipocyte lipid accumulation and systemic metabolic homeostasis. Alternative splicing produces multiple transcript variants.

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