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AdipoUpX™ Human IKBKB AAV Particle (Overexpression)
Cat. No.:
V1225XX367
Species:
Human
Target Gene:
IKBKB
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX367-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX367-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX367-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX367-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX367-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX367-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX367-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX367-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX367-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX367-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human IKBKB AAV Particle (Overexpression) has undergone comprehensive quality control and efficiently expresses the human IKBKB gene, a central kinase linking nutrient excess to inflammatory signaling. This product is an ideal tool for validating the molecular triggers of insulin resistance in chronic obesity models. Our platform supports the flexible inclusion of reporter genes and cell-specific promoters, with safety confirmed through rigorous purification and full QC screening for contaminants.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
IKBKB
Full Name:
Inhibitor of nuclear factor kappa B kinase subunit beta
Gene Symbol:
IKK2; IKKB; IKK-2; IMD15; IMD15A; IMD15B; NFKBIKB; IKK-beta
Gene ID:
3551
RefSeq ID-1:
NP_001177649.1
RefSeq ID-2:
NM_001190720.2
Summary:
IKBKB encodes a catalytic subunit of the IκB kinase complex, which activates NF-κB signaling by phosphorylating inhibitory proteins. This pathway integrates inflammatory and metabolic signals, and chronic IKBKB activation is associated with obesity-induced inflammation and insulin resistance. Both coding and noncoding transcript variants have been reported.
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