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AdipoUpX™ Human BBS10 AAV Particle (Overexpression)
Cat. No.:
V1225XX236
Species:
Human
Target Gene:
BBS10
Vector System:
AAV
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1225XX236-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX236-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1225XX236-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1225XX236-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1225XX236-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1225XX236-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1225XX236-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1225XX236-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1225XX236-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1225XX236-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human BBS10 AAV Particle (Overexpression) is a ready-to-use gene delivery tool specifically designed for the stable overexpression of the human BBS10 gene. As an essential chaperonin for BBSome assembly, it is a reliable asset for research into the molecular origins of genetic obesity. Our AAV platform offers the benefit of high customization, and all products undergo comprehensive QC, including titer, sterility, and mycoplasma testing to ensure the highest standards of experimental integrity.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
BBS10
Full Name:
Bardet-Biedl syndrome 10
Gene Symbol:
C12orf58
Gene ID:
79738
RefSeq ID-1:
NP_078961.3
RefSeq ID-2:
NM_024685.3
Summary:
BBS10 is another member of the BBS gene family, strongly linked to BBS Type 10. Unlike many structural BBS components, BBS10 is believed to function as a molecular chaperone, showing homology to type II chaperonins. Its primary role is likely to ensure the correct folding, stability, or trafficking of other key proteins required for ciliary or basal body assembly. This chaperone function is critical, as inhibition of BBS10 specifically impairs ciliogenesis in preadipocytes. Mutations in BBS10 cause BBS Type 10, underscoring that this chaperoning role is essential for ciliary health and preventing the development of the associated phenotype, which includes obesity and retinal degeneration.
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