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Vitamin B12 test kit

LipoKnoxa™ Human SREBF1 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX305
Species: Human
Target Gene: SREBF1
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human SREBF1 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX305-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GTGACTTCCCTGGCCTATTTG CDS Inquiry
V0126XX305-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle TATTCCGGGAACATCTCTTAG CDS Inquiry
V0126XX305-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle TGAGGCTCCTGTGCTACTTTG 3' UTR Inquiry
V0126XX305-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GTGACTTCCCTGGCCTATTTG CDS Inquiry
V0126XX305-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle TATTCCGGGAACATCTCTTAG CDS Inquiry
V0126XX305-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle TGAGGCTCCTGTGCTACTTTG 3' UTR Inquiry
V0126XX305-7 AAV3 Lung; Liver; Smooth muscle GTGACTTCCCTGGCCTATTTG CDS Inquiry
V0126XX305-8 AAV3 Lung; Liver; Smooth muscle TATTCCGGGAACATCTCTTAG CDS Inquiry
V0126XX305-9 AAV3 Lung; Liver; Smooth muscle TGAGGCTCCTGTGCTACTTTG 3' UTR Inquiry
V0126XX305-10 AAV4 CNS; Retina; Heart; Lung; Kidney GTGACTTCCCTGGCCTATTTG CDS Inquiry
V0126XX305-11 AAV4 CNS; Retina; Heart; Lung; Kidney TATTCCGGGAACATCTCTTAG CDS Inquiry
V0126XX305-12 AAV4 CNS; Retina; Heart; Lung; Kidney TGAGGCTCCTGTGCTACTTTG 3' UTR Inquiry
V0126XX305-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GTGACTTCCCTGGCCTATTTG CDS Inquiry
V0126XX305-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle TATTCCGGGAACATCTCTTAG CDS Inquiry
V0126XX305-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle TGAGGCTCCTGTGCTACTTTG 3' UTR Inquiry
V0126XX305-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GTGACTTCCCTGGCCTATTTG CDS Inquiry
V0126XX305-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle TATTCCGGGAACATCTCTTAG CDS Inquiry
V0126XX305-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle TGAGGCTCCTGTGCTACTTTG 3' UTR Inquiry
V0126XX305-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GTGACTTCCCTGGCCTATTTG CDS Inquiry
V0126XX305-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle TATTCCGGGAACATCTCTTAG CDS Inquiry
V0126XX305-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle TGAGGCTCCTGTGCTACTTTG 3' UTR Inquiry
V0126XX305-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GTGACTTCCCTGGCCTATTTG CDS Inquiry
V0126XX305-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle TATTCCGGGAACATCTCTTAG CDS Inquiry
V0126XX305-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle TGAGGCTCCTGTGCTACTTTG 3' UTR Inquiry
V0126XX305-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GTGACTTCCCTGGCCTATTTG CDS Inquiry
V0126XX305-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle TATTCCGGGAACATCTCTTAG CDS Inquiry
V0126XX305-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle TGAGGCTCCTGTGCTACTTTG 3' UTR Inquiry
V0126XX305-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human SREBF1 shRNA AAV Particle (Silencing) targets SREBP-1, the master transcriptional activator of fatty acid and triglyceride synthesis. Engineered with both high-potency U6 and physiologically refined miR30-based shRNA, this tool allows researchers to model hepatic steatosis and lipogenesis. Multiple AAV serotypes are available to ensure precise delivery. To ensure experimental success, every batch undergoes total quality control screening for sequence accuracy and functional titer.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: SREBF1
Full Name: Sterol regulatory element binding transcription factor 1
Gene Symbol: HMD; IFAP2; SREBP1; bHLHd1
Gene ID: 6720
RefSeq ID-1: NP_001005291.1
RefSeq ID-2: NM_001005291.3
Summary: SREBF1 is a transcription factor that controls the expression of genes required for cholesterol and fatty acid synthesis. Initially anchored to the endoplasmic reticulum, the protein is cleaved and moves to the nucleus when sterol levels are low. The SREBP-1c isoform is particularly responsive to insulin signaling, providing a direct link between high insulin levels and the increased production of fats in the liver, a condition frequently seen in obese patients.

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