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Vitamin B12 test kit

LipoKnoxa™ Human SDCCAG8 shRNA AAV Particle (Silencing)

Cat. No.: V0126XX277
Species: Human
Target Gene: SDCCAG8
Vector System: AAV
Modulation Type: Silencing (shRNA)
LipoKnoxa™ Human SDCCAG8 shRNA AAV Particle (Silencing)
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SPECIFIC INQUIRY
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Sub Cat. No. AAV Serotype Tissue Tropism TargetSeq Region Inquiry
V0126XX277-1 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle CTTTCCCAAACCCATACTAAT CDS Inquiry
V0126XX277-2 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle GAGGAACGACTTAGCTGAATA CDS Inquiry
V0126XX277-3 AAV1 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle ACGACCTTGTTCATACTATTA CDS Inquiry
V0126XX277-4 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle CTTTCCCAAACCCATACTAAT CDS Inquiry
V0126XX277-5 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle GAGGAACGACTTAGCTGAATA CDS Inquiry
V0126XX277-6 AAV2 CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle ACGACCTTGTTCATACTATTA CDS Inquiry
V0126XX277-7 AAV3 Lung; Liver; Smooth muscle CTTTCCCAAACCCATACTAAT CDS Inquiry
V0126XX277-8 AAV3 Lung; Liver; Smooth muscle GAGGAACGACTTAGCTGAATA CDS Inquiry
V0126XX277-9 AAV3 Lung; Liver; Smooth muscle ACGACCTTGTTCATACTATTA CDS Inquiry
V0126XX277-10 AAV4 CNS; Retina; Heart; Lung; Kidney CTTTCCCAAACCCATACTAAT CDS Inquiry
V0126XX277-11 AAV4 CNS; Retina; Heart; Lung; Kidney GAGGAACGACTTAGCTGAATA CDS Inquiry
V0126XX277-12 AAV4 CNS; Retina; Heart; Lung; Kidney ACGACCTTGTTCATACTATTA CDS Inquiry
V0126XX277-13 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle CTTTCCCAAACCCATACTAAT CDS Inquiry
V0126XX277-14 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle GAGGAACGACTTAGCTGAATA CDS Inquiry
V0126XX277-15 AAV5 CNS; Brain; Retina; Heart; Lung; Smooth muscle ACGACCTTGTTCATACTATTA CDS Inquiry
V0126XX277-16 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle CTTTCCCAAACCCATACTAAT CDS Inquiry
V0126XX277-17 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle GAGGAACGACTTAGCTGAATA CDS Inquiry
V0126XX277-18 AAV6 Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle ACGACCTTGTTCATACTATTA CDS Inquiry
V0126XX277-19 AAV7 CNS; Brain; Retina; Liver; Smooth muscle CTTTCCCAAACCCATACTAAT CDS Inquiry
V0126XX277-20 AAV7 CNS; Brain; Retina; Liver; Smooth muscle GAGGAACGACTTAGCTGAATA CDS Inquiry
V0126XX277-21 AAV7 CNS; Brain; Retina; Liver; Smooth muscle ACGACCTTGTTCATACTATTA CDS Inquiry
V0126XX277-22 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle CTTTCCCAAACCCATACTAAT CDS Inquiry
V0126XX277-23 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle GAGGAACGACTTAGCTGAATA CDS Inquiry
V0126XX277-24 AAV8 CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle ACGACCTTGTTCATACTATTA CDS Inquiry
V0126XX277-25 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle CTTTCCCAAACCCATACTAAT CDS Inquiry
V0126XX277-26 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle GAGGAACGACTTAGCTGAATA CDS Inquiry
V0126XX277-27 AAV9 CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle ACGACCTTGTTCATACTATTA CDS Inquiry
V0126XX277-28 Other Inquiry

Product Overview

Description: LipoKnoxa™ Human SDCCAG8 shRNA AAV Particle (Silencing) focuses on the targeted inhibition of a centrosomal-ciliary protein linked to Bardet-Biedl syndrome and nephronophthisis. Utilizing our dual-strategy platform (U6 and miR30 systems), researchers can explore the molecular basis of obesity in ciliopathies. Our platform offers multiple AAV serotypes for tissue-specific tropism, supported by exhaustive QC validation covering functional titer and sequence integrity.
Production Cell Line: HEK293
AAV ITR: AAV2 ITR
Promoter: U6; CMV; EF1α; CAG; UBC
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: The sequence identity and genomic integrity of all preparations were successfully confirmed via sequencing and PCR validation.
Sterility Test: Stringent QC assays have verified the sterility of this product lot, ensuring it is free of all detectable microbial contaminants.
Mycoplasma Test: Confirmed free of mycoplasma contamination via high-sensitivity QC assays; this product lot has successfully passed the production safety protocols.
Other QC: Tailored supplementary testing and transduction performance assays are available to evaluate gene silencing at the molecular level. We provide comprehensive in vitro and in vivo assessments to elucidate the impact of shRNA-targeted editing on gene expression profiles and downstream biological phenotypes.
Storage: To maintain optimal viral potency and structural integrity, it is essential to store the vector at -80°C immediately following its receipt.
Stability: Long-term storage at -80°C ensures product integrity for up to 24 months. For immediate experimental use, the thawed viral preparations are refrigerated at 4°C, maintaining robust performance for a period of 2–3 weeks.
Shipping Condition: Shipped on dry ice. Product integrity is guaranteed through temperature-controlled logistics for all viral vector types.
Handling Notes: To prevent titer loss caused by repeated freeze-thaw cycles, we recommend aliquoting the virus into single-use volumes upon receipt. Use low-protein-binding microcentrifuge tubes and store under specified conditions. Strict adherence to biosafety protocols is required; perform all handling within a designated biosafety cabinet.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: All products undergo stringent quality control; however, no warranty is provided for performance in specific applications, given the diversity of experimental variables. The user is ultimately responsible for ensuring proper storage, handling, and adherence to all local laws, biosafety standards, and safety regulations throughout the use of the product.

Target Profile

Gene Name: SDCCAG8
Full Name: SHH signaling and ciliogenesis regulator SDCCAG8
Gene Symbol: BBS16; CCCAP; SLSN7; NPHP10; hCCCAP; HSPC085; NY-CO-8; CCCAP SLSN7
Gene ID: 10806
RefSeq ID-1: NP_006633.1
RefSeq ID-2: NM_006642.5
Summary: SDCCAG8 encodes a protein that localizes to the centrosome, the cell's main microtubule-organizing center. It is essential for maintaining the structural integrity of the centrosome during both the resting phase and cell division. Recently, SDCCAG8 has been classified as a ciliary protein, as mutations in this gene lead to retinal-renal ciliopathy and are associated with Bardet-Biedl-like features. Its role in organizing cellular architecture is vital for the signaling pathways that prevent the multi-organ dysfunction and obesity typical of ciliary disorders.

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