AdipoUpX™ Human VPS13B Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human VPS13B Lentiviral Particle (Overexpression) is a high-titer system for the specific and stable expression of the human VPS13B gene, linked to Cohen syndrome and truncal obesity. Stable integration into the host genome allows for systematic investigation into Golgi-to-endosome trafficking and adipocyte differentiation. All viral particle products undergo comprehensive quality control to ensure safety and efficacy. Clients can customize the vector with fluorescent tags to visualize the protein's intracellular localization.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: VPS13B

Full Name: Vacuolar protein sorting 13 homolog B

Gene Symbol: CHS1; COH1; BLTP5B

Gene ID: 157680

RefSeq ID-1: NP_056058.2

RefSeq ID-2: NM_015243.2

Summary: VPS13B encodes a putative transmembrane protein that may function in vesicle-mediated protein transport and intracellular sorting. It is implicated in the development and function of the eye, hematological system, and central nervous system. Mutations in VPS13B cause Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified. Emerging evidence suggests that VPS13B dysfunction may contribute to obesity through altered cellular trafficking or metabolic regulation.

AdipoUpX™ Human VPS13B Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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