AdipoUpX™ Human BBIP1 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human BBIP1 Lentiviral Particle (Overexpression) is a high-titer system for the specific and stable expression of the human BBIP1 (BBS18) gene. It is a critical tool for investigating the structural integrity of the BBSome and its role in primary cilia-mediated signaling. Stable genomic integration ensures a reliable platform for researching syndromic obesity. Our vector system features a modular design for easy customization, and all products undergo comprehensive quality control to ensure experimental safety and the highest reproducibility.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: BBIP1

Full Name: BBSome interacting protein 1

Gene Symbol: BBS18; BBIP10; bA348N5.3; NCRNA00081

Gene ID: 92482

RefSeq ID-1: NP_001182233.1

RefSeq ID-2: NM_001195304.2

Summary: BBIP1 (formerly BBS18) encodes a protein that is an essential component and one of the eight subunits required for the complete assembly of the BBSome complex. This complex is vital for the correct trafficking of signaling receptors (such as the somatostatin receptor) to and from the primary cilium, which is the cellular antenna coordinating key developmental and metabolic pathways. Mutations in BBIP1 result in Bardet-Biedl syndrome type 18, underscoring the necessity of this subunit for ciliary function and the prevention of the BBS phenotype, which universally includes severe obesity.

AdipoUpX™ Human BBIP1 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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