AdipoUpX™ Human TFAP2B Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human TFAP2B Lentiviral Particle (Overexpression) is a powerful, high-titer gene delivery tool specifically designed for the long-lasting overexpression of the human TFAP2B gene. Mutations in this transcription factor are linked to Char syndrome and truncal obesity, making its stable integration essential for researching adipogenesis and fat distribution. Clients can freely customize key functional components, such as promoters and reporter genes, to meet diverse experimental needs. Comprehensive quality control is performed to ensure both product safety and the reproducibility of results.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: TFAP2B

Full Name: Transcription factor AP-2 beta

Gene Symbol: PDA2; AP-2B; AP2-B; AP-2beta

Gene ID: 7021

RefSeq ID-1: NP_003212.2

RefSeq ID-2: NM_003221.4

Summary: As a member of the AP-2 transcription factor family, TFAP2B serves as a developmental architect, stimulating cell growth while suppressing the premature maturation of specific cell lineages. While mutations in this gene are known to cause Char syndrome, affecting neural crest derivatives, TFAP2B is also a significant genetic locus in obesity research, where it helps dictate the differentiation program of adipose tissue.

AdipoUpX™ Human TFAP2B Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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