AdipoUpX™ Human TFAM Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human TFAM Lentiviral Particle (Overexpression) is professionally engineered for the long-lasting, stable overexpression of the human TFAM gene. As a critical factor for mitochondrial genome maintenance, its stable expression facilitates investigation into mitochondrial biogenesis and its role in oxidative capacity. The product is ready-to-use and high-titer, and all particles undergo rigorous internal quality control validation (titer, sterility, and mycoplasma) to ensure reliability. Clients can freely customize functional components, including reporter genes and markers, to meet their unique experimental needs.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: TFAM

Full Name: Transcription factor A, mitochondrial

Gene Symbol: TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; MTDPS15

Gene ID: 7019

RefSeq ID-1: NP_001257711.1

RefSeq ID-2: NM_001270782.2

Summary: TFAM is an essential regulator of mitochondrial health, containing motifs that allow it to bind and organize mitochondrial DNA. It is required for the replication, repair, and transcription of the mitochondrial genome. Since mitochondria are the sites of fat and sugar burning, TFAM activity directly determines a cell's metabolic capacity. Genetic variations in TFAM are linked to metabolic decline as well as neurodegenerative conditions like Alzheimer's.

AdipoUpX™ Human TFAM Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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