AdipoUpX™ Human STAT3 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human STAT3 Lentiviral Particle (Overexpression) is a high-titer system for the specific and stable expression of the human STAT3 gene. This transcription factor is central to the leptin signaling pathway and the suppression of appetite. The lentivirus characteristic of genome integration establishes reliable cell models for studying JAK/STAT activation and metabolic resistance. Comprehensive quality control is performed on all particles to ensure safety, efficacy, and the highest experimental standards, with support for flexible customization of promoters.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: STAT3

Full Name: Signal transducer and activator of transcription 3

Gene Symbol: APRF; HIES; ADMIO; ADMIO1

Gene ID: 6774

RefSeq ID-1: NP_001356441.1

RefSeq ID-2: NM_001369512.1

Summary: STAT3 is a transcription factor that translates external cytokine signals (such as IL-6 or Leptin) into gene expression changes in the nucleus. It is a central node for cell growth, survival, and immune response. In the context of obesity, STAT3 is the primary messenger for leptin signaling in the hypothalamus; resistance in this pathway prevents the brain from receiving the "stop eating" signal, leading to hyperphagia and weight gain.

AdipoUpX™ Human STAT3 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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